Pharmacologic correction of microcirculatory disorders and hemosorption in the treatment of patients with ischemic heart disease

Patterns of red blood cell hemostasis and microcirculation changes are analysed in 115 chronic coronary patients in the course of purposeful medication and at extracorporeal carbohemoperfusion. Differences in the mechanisms of action of trental, phosphaden and essentiale are identified by means of television capillaroscopy, termography, scanning electron microscopy; the mechanism of the antianginal effect of extracorporeal carbohemoperfusion is specified. A considerable disaggregating effect associated with trental and phosphaden, as well as an essentiale-associated improvement in red blood cell morphology and membrane permeability were demonstrated. Extracorporeal carbohemoperfusion is followed by an improvement of red blood cell hemostasis and microcirculation characteristics and a decrease in plasma lipoproteins.