Ceftobiprole- and Ceftaroline-Resistant Methicillin-Resistant Staphylococcus aureus |
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| Authors: | Liana C. Chan Li Basuino Binh Diep Stephanie Hamilton Som S. Chatterjee Henry F. Chambers |
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| Affiliation: | aDivision of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA;bDivision of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA |
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| Abstract: | The role of mecA mutations in conferring resistance to ceftobiprole and ceftaroline, cephalosporins with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, was determined with MRSA strains COL and SF8300. The SF8300 ceftaroline-passaged mutant carried a single mecA mutation, E447K (E-to-K change at position 447), and expressed low-level resistance. This mutation in COL conferred high-level resistance to ceftobiprole but only low-level resistance to ceftaroline. The COL ceftaroline-passaged mutant, which expressed high-level resistance to ceftobiprole and ceftaroline, had mutations in pbp2, pbp4, and gdpP but not mecA. |
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