阿托伐他汀对冠心病患者颈动脉内-中膜厚度的影响

目的：应用高频超声观察冠心病（cAD）患者，经阿托伐他汀治疗后对颈动脉内-中膜（IMT）的改善作用。方法：经冠脉造影（cAG）确诊为CAD并伴有颈动脉粥样硬化患者59例，利用高频超声血管技术检测阿托伐他汀对CAD患者治疗前后颈动脉最厚处和最薄处IMT。结果：阿托伐他汀组治疗2年后，冠心病患者颈动脉IMT最厚处和最薄处与治疗前相比均无显著性改变（P〉0．05）；常规治疗组治疗2年后，颈动脉IMT最厚处与治疗前相比无显著性改变（P〉0．05），IMT最薄处显著增厚（P〈0．05）。结论：阿托伐他汀具有稳定斑块、延缓粥样硬化斑块进展的作用。

The influence of atorvastatin on intimal - medial thickness of carotid artery in patients with coronary artery disease

Objective:To observe the effect of atorvastatin on intimal-medial thickness(IMT) of carotid artery in patients with coronary artery disease(CAD) by high-frequency ultrasonic imaging.Methods:A total of 59 patients with CAD and carotid artery artherosclerosis diagnosed by coronary angiography(CAG) and high-frequency ultrasound were submitted to this study.High-frequency ultrasonic imaging was used to detect the changes of carotid artery IMT after administration of atorvastatin.Results: After atorvastatin therapy for 2 years,both thickest and thinnest IMT of carotid artery in CAD patients had no significant change(P>0.05).In conventional therapy group,the thickest IMT of carotid artery had no significant change(P>0.05),but the thinnest IMT thickened significantly(P<0.05).Conclusion: Atorvastatin is effective to stabilize the plaque and retard the development of atherosclerosis.