| 四氯化碳中毒大鼠肝脏Ca~(2 )-ATP酶和磷酸化酶a活性的研究 |
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| 引用本文： | 赵宝昌,姚晓丹,顾淑珍,杜国忠,欧阳启楣,林钧材.四氯化碳中毒大鼠肝脏Ca~(2 )-ATP酶和磷酸化酶a活性的研究[J].中华劳动卫生职业病杂志,1990(4). |
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| 作者姓名： | 赵宝昌 姚晓丹 顾淑珍 杜国忠 欧阳启楣 林钧材 |
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| 作者单位： | 大连医学院生化教研室
(赵宝昌，姚晓丹，顾淑珍，杜国忠，欧阳启楣)，大连医学院生化教研室(林钧材) |
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| 摘 要： | 本实验采用雄性S.D.大鼠,经日一次灌注2.2ml/kg 四氯化碳,于染毒后12、24、48小时测定肝微粒体Ca~2 -ATP 酶和肝细胞液磷酸化酶a 活性变化。结果发现,染毒后大鼠肝微粒体Ca~2 -ATP 酶活性显著降低,以染毒后24小时为甚;肝细胞液磷酸化酶a 活性显著增高,以染毒后24小时为最高。说明四氯化碳致肝损伤时,肝内质网隔离钙的能力降低,胞液中钙浓度升高。本实验对于阐明四氯化碳中毒性肝病发病机理有一定的意义。
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| 关 键 词： | Ca~(2 )—ATP 酶 磷酸化酶 a 四氯化碳中毒 钙恒稳 |
Studies on the Activities of Ca~(2 )-ATPase and Phosphorylase a in the Liver of CCl_4-poisoned Rats |
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| Zhao Bao-chang.Studies on the Activities of Ca~(2 )-ATPase and Phosphorylase a in the Liver of CCl_4-poisoned Rats[J].Chinese Journal of Industrial Hygiene and Occupational Diseases,1990(4). |
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| Authors: | Zhao Bao-chang |
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| Institution: | Zhao Bao-chang |
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| Abstract: | Carbon tetrachloride was administered to male Sprague-Dawley rats in asingle hepatotoxic dose of 2.2ml/kg.The activity of liver-microsomalCa~(2 )-ATPase and liver-cytosol phosphorylase a was measured at 13,24 and48hr postadministration.The results were that the activity of Ca~(2 )-ATPasewas remsrkably decreased,while of phosphorylase a was highly increased.These data demonstrated that the ability of hepatic endoplasmic reticulum tosequester calcium is destroyed during CCl_4 poisoning.causing calcium to ac-cumulate in liver-cytosol.This experiment has certain significance in revealingthe mechanism of hepatosis induced by CCl_4 poisoning. |
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| Keywords: | Ca~(2 )-ATPase Phosphorylase a CCI_4 poisoning Ca~(2 ) homeostasis |
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