| 茶多酚磷脂复合物的制备 |
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| 引用本文： | 初阳,林建阳,杨倩,陈大为.茶多酚磷脂复合物的制备[J].山西医药杂志,2012(11):1087-1089. |
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| 作者姓名： | 初阳 林建阳 杨倩 陈大为 |
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| 作者单位： | 中国医科大学附属第一医院;沈阳药科大学 |
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| 基金项目： | 沈阳市科学技术计划项目(1091142-9-00) |
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| 摘 要： | 目的研究茶多酚磷脂复合物的制备。方法对反应溶剂、药脂比、溶剂量、反应时间、反应温度进行单因素考察,筛选最优条件,进行正交试验,确立最优工艺。结果以30mL无水乙醇为反应溶剂,药物与磷脂比例为1∶1.5,30℃水浴回流搅拌0.5h,所得磷脂复合物的平均结合率为98.85%。结论采用工艺简单、成本较低的方法制备茶多酚磷脂复合物,可提高茶多酚提取物亲脂性,为进一步研究茶多酚磷脂复合物的体内药物动力学提供参考。
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| 关 键 词： | 植物提取物 磷脂类 茶多酚 复合率 亲脂性 |
Preparation of tea polyphenols phytosomes |
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| CHU Yang,LIN Jian-yang,YANG Qian,CHEN Da-wei.Preparation of tea polyphenols phytosomes[J].Shanxi Medical Journal,2012(11):1087-1089. |
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| Authors: | CHU Yang LIN Jian-yang YANG Qian CHEN Da-wei |
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| Institution: | .The First Affiliated Hospital of China Medical University,Shenyang 110001,China |
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| Abstract: | Objective To study the preparation of tea polyphenols phytosomes(TP-PC).Methods A single-elements' test was conducted contraposing the reaction solvent,drug-lipid ratio,solution amount,reaction time and temperature,filtering the optimum conditions.Results When using 30 mL anhydrous alcohol as the reaction solvent,drug-lipid ratio is 1:1.5,and then water bath for 0.5 h at the temperature of 30 ℃,the average binding ratio of phospholipid complex is 98.85%.Conclusion The preparation technology of TP-PC is simple and economic.TP-PC can significantly improve oil-water distribution coefficients,which can be the reference for the bioavailability in vivo in the further researches. |
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| Keywords: | Plant extracts Phospholipids Tea polyphenol Combination Lipophicity |
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