| 侧脑室注射TRH对大鼠胃内压的影响 |
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| 引用本文： | 凌文华,张景行,张惠秀,马嵘,徐光尧. 侧脑室注射TRH对大鼠胃内压的影响[J]. 中国药理学通报, 1989, 0(5) |
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| 作者姓名： | 凌文华 张景行 张惠秀 马嵘 徐光尧 |
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| 作者单位： | 安徽医科大学生理教研室 安徽医科大学生理教研室 合肥 |
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| 摘 要： | 大鼠侧脑室注射TRH10μg明显增加胃内压和引起较大幅度的胃的相位性收缩。延髓双侧迷走神经背核破坏后,TRH促进胃运动的效应减弱;双侧膈下迷走神经切断后,TRH的效应完全被阻断;外周注入阿托品也具有完全消除TRH效应的作用。本实验提示迷走神经背核是TRH中枢促进胃运动的一个重要神经结构,迷走神经是TRH效应的传出途径。
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| 关 键 词： | 促甲状腺激素释放激素(TRH) 迷走神经背核 胃内压 胃相位性收缩 |
EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF TRH ON INTRAGASTRIC PRESSURE IN RATS |
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| Abstract: | In the present study, the results were as follows: ( 1 ) Thyro-tropin-releasing hormone ( TRH ) injected into the intracerebroven-tricle increased intragastric pressure & evoked the phasic contraction of stomach significantly. ( 2 ) The increased response was decreased by bilateral destruction of dorsa. motor nucleus of vagus. ( 3 ) The increase was abolished completely by either vagotomy or atropine.The aforementioned results indicate that the action of dors. motor nucleus of vagus is partly involved the central mechanism of gastric movement induced by TRH & the vagal is the efferent pathway. |
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| Keywords: | Thyrotropin-releasing hormone Dors motor nucleus of vagus Intragastric pressure Phasic contraction |
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