MMP-2与近视关系的研究进展

近年来研究表明近视的发生发展与巩膜细胞外基质（ECM）的重塑关系密切，基质金属蛋白酶（MMPs）作为调控巩膜ECM动态平衡最重要的一大酶系，也受到越来越多的重视，其中对于MMP-2的研究最为广泛，作为探讨近视发病机制及治疗的靶因子，不仅有大量研究证明其活性增加与近视发展明显相关，很多通过抑制MMP-2来防治近视的研究也取得了丰硕的成果。现就MMP-2多年来在近视方面的研究进展做一综述。

MMP-2 and myopia

Recent studies indicate that the development of myopia is closely related to the remodeling of scleral extracellular matrix metalloproteinases， as the most important enzymes of regulating the scleral extracellular matrix have gained more and more attention， in which MMP-2 is the most widely studied. As a target factor in the study of the pathogenesis and treatment of myopia， not only a large number of studies have shown that its activity increased significantly associated with the development of myopia， many researches on myopia treatment also achieved fruitful results by inhibiting MMP-2. Years of researches of MMP-2 in myopia study is reviewed in this paper.