Correlation of serum hepcidin with residual renal function and micro-inflammation in peritoneal dialysis patients

Objective To study the correlation of serum hepcidin with residual renal function and micro-inflammation state in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods Thirty-four stable CADP patients were involved in this study as observers (CAPD group), who had accepted CAPD treatment more than three months; twenty non-dialysis patients with stage 5 of chronic kidney disease were selected as control group. According to the level of high sensitivity Creactive protein (hs-CRP), CAPD patients were divided into two subgroups. There were 14 patients in the hs-CRP elevated group (hs-CRP＞3.00 mg/L) and 20 patients in the hs-CRP normal group. In addition, there had been 14 patients with residual renal function in CAPD group. Serum hepcidin was measured by ELISA. Serum Ferritin (FER), hs-CRP, routine blood and biochemistry were measured by routine methods. Calculated estimated glomerular filtration rate (eGFR). Pearson correlation and linear regression were used to assess the correlation of serum hepcidin with other laboratory parameters in CAPD patients. Results (1) Serum hepcidin was significantly higher in CAPD patients than control group, but eGFR was significantly lower (P﹤0.01). (2) Serum hepcidin levels of no residual renal function patients increased more significantly in CAPD group (P﹤0.05). (3) Serum hepcidin levels were higher in hs-CRP elevated group than hs-CRP normal group (P﹤0.05). (4) Pearson correlation analyses revealed that serum hepcidin was positively correlated with hs-CRP (r=0.501) and FER (r=0.847, all P﹤0.01), and was negatively correlated with Hb (r=-0.919), TRF (r=-0.751), TIBC (r=-0.532, all P＜0.05). (5) Multiple linear regression analysis showed that ferritin and hs-CRP were closely associated with serum hepcidin level in CAPD. Conclusions Serum hepcidin level markedly elevate in CAPD patients, especially in the patients with no residual renal function and micro inflammatory state increased more significantly.