| The Investigation on bFGF Expression and FGFR1 Gene Mutation in the Tumors of Salivary Gland |
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| 引用本文： | ZHANG Dong-liang 1,SUN Hong-chen 1,WANG Li-ying 2,ZHANG Yun-song 3.1:School of Dentistry,Jilin University,Changchun 130041,2:School of Basic Medicine,Jilin University,3:461 st Hospital of PLA,the Department of Stomatology.. The Investigation on bFGF Expression and FGFR1 Gene Mutation in the Tumors of Salivary Gland[J]. 口腔医学研究, 2002, 18(2): 95-97 |
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| 作者姓名： | ZHANG Dong-liang 1 SUN Hong-chen 1 WANG Li-ying 2 ZHANG Yun-song 3.1:School of Dentistry Jilin University Changchun 130041 2:School of Basic Medicine Jilin University 3:461 st Hospital of PLA the Department of Stomatology. |
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| 作者单位： | ZHANG Dong-liang 1，SUN Hong-chen 1，WANG Li-ying 2，ZHANG Yun-song 3.1:School of Dentistry，Jilin University，Changchun 130041;2:School of Basic Medicine，Jilin University;3:461 st Hospital of PLA，the Department of Stomatology. |
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| 摘 要： | 目的 :探讨bFGF表达及FGFR1基因突变与涎腺肿瘤发生发展的关系。方法 :采用免疫组织化学技术和RT -PCR -SSCP法 ,对 14例多形性腺瘤、9例腺样囊性癌组织和 11例正常涎腺组织中bFGF表达及相应组织内FGFR1胞内段结构基因进行了检测。结果 :bFGF在多形性腺瘤、腺样囊性癌中的表达明显高于正常涎腺组织 ;FGFR1在 14例多形性腺瘤中 4例检出基因突变 ,9例腺样囊性癌组织中 2例检出突变 ,且发现突变基因位于FGFR1胞内段的近膜区及部分激酶I区。结论 :FGFR1细胞内段激酶活性区的突变可能造成bFGF /FGFR1信号传递异常 ,进而参与延腺肿瘤的发生发展
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| 关 键 词： | 多形性腺瘤 腺样囊性癌 碱性成纤维细胞生长因子 成纤维细胞生长因子受体Ⅰ |
The Investigation on bFGF Expression and FGFR1 Gene Mutation in the Tumors of Salivary Gland |
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| ZHANG Dong-liang,SUN Hong-chen,WANG Li-ying,ZHANG Yun-song. The Investigation on bFGF Expression and FGFR1 Gene Mutation in the Tumors of Salivary Gland[J]. Journal of Oral Science Research, 2002, 18(2): 95-97 |
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| Authors: | ZHANG Dong-liang SUN Hong-chen WANG Li-ying ZHANG Yun-song |
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| Abstract: | |
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| Keywords: | Pleomorphic adenoma Adenoid cystic carcinoma Basic fibroblast growth factor (bFGF) Fibroblast growth factor receptor 1 (FGFR1) |
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