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| 膀胱梗阻大鼠逼尿肌不稳定与三磷酸肌醇关系的实验研究 | |
| 引用本文： | 王军,梁颖,庄仕华,李彤,宋波,金锡御,叶章群.膀胱梗阻大鼠逼尿肌不稳定与三磷酸肌醇关系的实验研究[J].新疆医科大学学报,2007,30(8):803-806. |
| 作者姓名： | 王军 梁颖 庄仕华 李彤 宋波 金锡御 叶章群 |
| 作者单位： | 1. 武警新疆总队医院泌尿外科,新疆,乌鲁木齐,830000 2. 新疆医科大学公共卫生学院营养与食品卫生教研室,新疆,乌鲁木齐,830054 3. 武警新疆总队医院肝胆外科,新疆,乌鲁木齐,830000 4. 第三军医大学西南医院全军泌尿外科研究所,重庆,400038 5. 华中科技大学同济医学院附属同济医院泌尿外科,湖北,武汉,430030 |
| 摘 要： | 目的探讨膀胱梗阻大鼠逼尿肌不稳定(detrusor instability ,DI)与三磷酸肌醇inositol(1,4,5)-trisphosphat ,IP3]含量变化的关系.方法建立DI大鼠模型,分别检测DI大鼠、逼尿肌稳定(detrusor stability, DS)大鼠及经卡巴可(Carbachol) 处理的DS大鼠逼尿肌原代培养细胞IP3含量.结果DI大鼠逼尿肌原代培养细胞IP3含量显著高于DS大鼠(P＜0.01),经10-5mmol/L卡巴可刺激后,DS 大鼠逼尿肌原代培养细胞IP3含量较刺激前显著升高(P＜0.01).结论肌醇脂质信号传导通路可能参与了逼尿肌不稳定的形成,IP3含量的升高可能在其中起着重要作用. |
| 关 键 词： | 三磷酸肌醇 逼尿肌不稳定 大鼠 |
| 文章编号： | 1009-5551（2007）08-0803-04 |
| 修稿时间： | 2007-03-05 |
Experimental study of relationship between detrusor instability secondary to bladder outlet obstruction and IP3 in rats |
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| WANG Jun, LIANG Ying, ZHUANG Shi-hua, et al.Experimental study of relationship between detrusor instability secondary to bladder outlet obstruction and IP3 in rats[J].Journal of Xinjiang Medical University,2007,30(8):803-806. | |
| Authors: | WANG Jun LIANG Ying ZHUANG Shi-hua |
| Institution: | Department of Urinary Surgery, Xinjiang Uygur Autonomous Regional Corps Hospital, Chinese Peoplets Armed Police Forces, Urumqi 830000, China |
| Abstract: | Objective: To investigate the relationship between detrusor instability secondary to bladder outlet obstruction and the content change of inositol (1,4,5)-trisphosphate (IP3) in rats. Methods: To set up the model of detrusor instability (DI) of rats, IP3 contents of detrusor cultured cell in DI rats, detrusor stability (DS) rats which stimulated by 10-5M carbachol in DS rats were detected. Results: IP3 contents of detrusor cultured cell of DI rats were significantly higher than those of DS rats (P<0.01), IP3 contents of DS rats detrusor cultured cell stimulated by 10-5M carbachol were also obviously higher than those of DS rats no stimulated (P<0.01). Conclusions: Inositol-lipid signal transduction pathway might participate the pathogenesis of DI and the increasing of IP3 contents might play a important role . |
| Keywords: | inositol(1 4 5)-trisphosphate detrusor instability rat |
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