| 正常与自发性高血压大鼠血浆,组织内皮素分布变化的观察 |
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| 引用本文： | 程光华,陶晓根.正常与自发性高血压大鼠血浆,组织内皮素分布变化的观察[J].放射免疫学杂志,1997,10(4):193-195. |
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| 作者姓名： | 程光华 陶晓根 |
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| 作者单位： | [1]弋矶山医院核医学科 [2]心血管内科 |
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| 摘 要： | 本文采用放射免疫分析法测定了自发性高血压大鼠（ＳＨＲ）与正常血压大鼠（ＷＫＹ）血浆、脑和主动脉知管中内皮素量的变化。结果发现，ＳＨＲ血浆、脑和主动脉中ＥＴ含量均显著增高（Ｐ分别〈０．０１、〈０．００２和〈０．０１）；ＷＫＹ脑较血管组织含量低（Ｐ〈０．０１），ＳＨＲ两者则无显著性差异（Ｐ〉０．０５）。提示，ＳＨＲ血浆和组织中内皮素分布的变化与自发性高血压的发生、发展可能有密切的。
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| 关 键 词： | 内皮素 高血压 放射免疫分析 |
OBSERVATIONS OF ENDOTHELIN LEVEL VARIATIONS IN THE PLASMA AND THE TISSUES OF SHR AND, WKY |
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| Cheng Guanghua,Tao Xiaogen Yijishan Hospital,Wannan Medicol College,Wuhu,Anhui.OBSERVATIONS OF ENDOTHELIN LEVEL VARIATIONS IN THE PLASMA AND THE TISSUES OF SHR AND, WKY[J].Journal of Radioimmanology,1997,10(4):193-195. |
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| Authors: | Cheng Guanghua Tao Xiaogen Yijishan Hospital Wannan Medicol College Wuhu Anhui |
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| Abstract: | We measured the dynamic changes of endothelin(ET) levels in the plaspma the brain and the aerta of spontaneously hypertensive rat(SHR) and Wister-Kyoto rat(WKY) with RIA, The results showed that the ET levels in theplasma, the brain and the aorta of SHR were significantly higher (p<0.01, p<0.002, p<0.01 respectively) than those in WKY. The ET levels in the brain of WKY were lower than those in the aorta (p<0.01), while the ET levels; in the brain and the aorta of SHR showed no obvious differences (p> 0.05). These suggested that the dynamic changes of the distribution of the ET levels in plasm aud tissue of SHY might be closely related to the occu-rrence and development of hypertension. |
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| Keywords: | Eedothelin(ET) Spohtaneously hypertensive rat |
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