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| 抗菌钛合金Ti6Al4V-6Cu生物安全性初步研究 | |
| 引用本文： | 李抒缦,许雄程,钟泉,陈超,骆凯.抗菌钛合金Ti6Al4V-6Cu生物安全性初步研究[J].福建医科大学学报,2017(6):386-390. |
| 作者姓名： | 李抒缦 许雄程 钟泉 陈超 骆凯 |
| 作者单位： | 1.福建省老年医院 口腔科,福州 350003; 2.福建医科大学 附属口腔医院牙周科,福州 350002 |
| 基金项目： | 福建省发改委第三批省级预算内投资计划项目，福建省自然科学基金项目 |
| 摘 要： | 目的 通过体内、外实验对抗菌钛合金 Ti6Al4V-6Cu的生物安全性进行初步探讨,为抗菌钛合金Ti6Al4V-6Cu的临床应用提供实验依据. 方法 采用选择性激光熔化技术制备抗菌钛合金 Ti6Al4V-6Cu.通过体外细胞毒性试验、短期全身毒性实验和溶血实验对抗菌钛合金的生物安全性进行评价. 结果 选择性激光熔化技术制备抗菌钛合金Ti6Al4V-6Cu无细胞毒性,不引起大鼠体质量减轻及肝、肾病理性改变,溶血率较低.结论 选择性激光熔化技术制备抗菌钛合金Ti6Al4V-6Cu具有良好的生物安全性,有望将来应用于临床. |
| 关 键 词： | 合金 金属 细菌 炎症 |
Preliminary Study on the Biological Safety of the Antibacterial Titanium Alloy Ti6Al4V-6Cu |
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| LI Shuman,XU Xiongcheng,ZHONG Quan,CHEN Chao,LUO Kai.Preliminary Study on the Biological Safety of the Antibacterial Titanium Alloy Ti6Al4V-6Cu[J].Journal of Fujian Medical University,2017(6):386-390. | |
| Authors: | LI Shuman XU Xiongcheng ZHONG Quan CHEN Chao LUO Kai |
| Institution: | 1.Department of Stomatology, Fujian Province Geriatric Hospital, Fuzhou 350003, China; 2.Department of Periodontology, Fujian Province Stomatological Hospital, Fuzhou 350002, China |
| Abstract: | Objective T his research evaluated the biological safety of selective-laser-melted anti-bacterial titanium alloy Ti6Al4V-6Cu,and the results provided the expeimental basis for clinical applica-tion of the antibacterial titanium alloy Ti6Al4V-6Cu. Methods Antibacterial titanium alloy Ti6Al4V-6Cu was prepared by selective laser melting technology. Cytotoxicity test,hemolysis test and acute gen-eral toxicity test were carried out to evaluate the biological safety of the antibacterial titanium alloy Ti6Al4V-6Cu. Results Selective-laser-melted antibacterial titanium alloy Ti6Al4V-6Cu had no cytotox-icity,no acute systemic toxic and no hemolysis. Conclusions Selective-laser-melted antibacterial titani-um alloy Ti6Al4V-6Cu had good biosecurity. |
| Keywords: | alloys metals bacteria inflammation |
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