| 复方非洛地平/酒石酸美托洛尔渗透泵控释片的研制 |
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| 引用本文： | 颜琨,李志平,刘洪玉,姚蕊,梅兴国.复方非洛地平/酒石酸美托洛尔渗透泵控释片的研制[J].军事医学科学院院刊,2011,35(3):214-218. |
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| 作者姓名： | 颜琨 李志平 刘洪玉 姚蕊 梅兴国 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家科技重大专项资助项目，重大新药创制科技重大专项资助项目 |
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| 摘 要： | 目的制备复方非洛地平/酒石酸美托洛尔渗透泵控释片,并优选最佳处方。方法采用高效液相色谱法测定不同处方制剂累积释药百分率,建立体外评价方法,并通过相似因子和正交设计筛选出最佳处方。结果 渗透泵片的片芯处方、包衣增重是影响释药的主要因素。优化的处方为15 mg聚氧乙烯、45 mg NaCl、11%包衣增重。结论按优化处方制备的渗透泵控释片符合零级释放特征,且两种药物释放同步。
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| 关 键 词： | 非洛地平 酒石酸美托洛尔 复方制剂 渗透泵 正交设计 控释片 |
Preparation of osmotic pump controlled release tablets of compound felodipine with metoprolol tartrate |
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| YAN Kun,LI Zhi-ping,LIU Hong-yu,YAO Rui,MEI Xing-guo.Preparation of osmotic pump controlled release tablets of compound felodipine with metoprolol tartrate[J].Bulletin of the Academy of Military Medical Sciences,2011,35(3):214-218. |
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| Authors: | YAN Kun LI Zhi-ping LIU Hong-yu YAO Rui MEI Xing-guo |
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| Institution: | YAN Kun,LI Zhi-ping,LIU Hong-yu,YAO Rui,MEI Xing-guo(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | Objective To prepare osmotic pump controlled release tablets of felodipine with metoprolol tartrate and to optimize the formulation.Methods The cumulative rates of drug release of differently formulated preparations were measured by HPLC method.The tablets were evaluated in vitro to select the best formula using similarity factors and orthogonal design.Results The formulation of core tablets and different coating weights of membrane showed marked effects on drug release.The selected formula was 15 mg PEO,45... |
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| Keywords: | felodipine metoprolol tartrate compound preparation osmotic pump orthogonal design controlled release tablets |
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