托吡酯治疗酒依赖临床疗效观察

目的观察托吡酯治疗酒依赖的临床疗效与安全性。方法采用随机双盲对照研究方法对符合入组标准的78例酒依赖患者分为单一服用托吡酯组和安慰剂治疗组,疗程24周。在入组前和入组后2、4、8、12、24周末进行酒精依赖疾患识别测验（Alcohol Use Disorder Test,AUDIT）,强制性饮酒问卷（The Obsessive Compulsive Drinking Scale,OCDS）,症状自评量表（SCL-90）,副反应量表（TESS）评定,治疗结束对两组总体疗效进行对比。结果托吡酯组在戒酒总体疗效、对酒渴求程度、异常心理状态改善等方面明显优于安慰剂组,治疗中出现一些轻度药物副反应,随治疗进展逐渐缓解。结论托吡酯对戒酒治疗疗效肯定,能有效改善饮酒行为,降低酒依赖程度,加强心理防御机制,同时药物不良反应轻,持续时间较短,提高患者治疗依从性,降低复饮率,对酒依赖的治疗安全有效。

Observation on Clinical Effect of Topiramate in the Treatment of Alcohol Dependence

Objective To observe the clinical effect and safty of Topiramate in the treatment of the patients with alcohol dependence.Methods A total of 78 cases of patients with alcohol dependence were divided into Topiramate and placebo treatment groups for 12 weeks according to the randomized double-blind study.Then after 2,4,8,12 and 24 weeks of treatment,the effect was evaluated and compared by AUDIT,OCDS,TESS and SCL-90 scales,and the overall efficacy was compared in the end of treatment.Results Topiramate was significantly better than placebo in the overall effect,craing degree and abnormal psychology.There were some mild drug side-effects easing gradually while the treatment progress.Conclusions Topiramate is effective in treating alcohol dependence.It can improve drinking behaviors effectively,reduce the degree of alcohol dependence,strengthen mechanism of psychic defenses;it can improve adherence,reduce relapse for its mild and short-time drug side-effects.Topiramate is safe and effective in the treatment of alcohol dependence.