碳氧血红蛋白与一氧化碳中毒的相关性研究

目的探讨一氧化碳中毒患者碳氧血红蛋白（COHb）水平与中毒病情的相关性。方法对就诊的312例一氧化碳中毒患者的碳氧血红蛋白水平进行测定,并根据不同的性别、年龄、意识及生存情况比较碳氧血红蛋白含量的差异。结果①就诊的一氧化碳中毒患者中成年人（≥18岁）较未成年人（〈18岁）COHb水平显著升高（23.6±7.4）%比（19.9±9.1）%,P〈0.01];②男性患者较女性患者COHb水平显著升高（23.5±8.7）%比（20.1±9.9）%,P〈0.01];③出现意识障碍的患者较未出现者COHb水平显著升高（24.8±10.2）%比（20.9±11.2）%,P〈0.01];④死亡患者较生存者具有显著升高的COHb含量（36.2±15.4）%比（21.9±10.6）%,P〈0.01];⑤COHb%≥30%的患者较COHb%〈30%的患者意识障碍发生率显著升高（61.3%比44.0%;P〈0.05）。结论较高的COHb水平往往预示着一氧化碳中毒病情较重。

Correlation of carboxyhemoglobin and carbon monoxide poisoning

Objective To investigate the correlation of carboxyhemoglobin（COHb） levels in patients with carbon monoxide poisoning to the disease severity.Methods The serum COHb levels in 312 patients with CO poisoning were detected,and the COHb measurements were analyzed with regard to gender,age,loss of consciousness and death.Results ①The COHb level in adult patients（≥18 years）was significantly higher than that of minors（18 years）（23.6±7.4）% vs（19.9±9.1）%,P0.01];②The COHb level in male patients was significantly higher than that of female patients （23.5±8.7）% vs（20.1±9.9）%,P0.01];③The COHb level in unconscious patients was significantly higher than that of conscious patients （24.8±10.2）% vs（20.9±11.2）%,P0.01];④The COHb level in dead patients was significantly higher than that of survivors （36.2±15.4）% vs（21.9±10.6）%,P0.01];⑤The conscious disturbance in patients with COHb%≥30% was significantly higher than that of patients with COHb%30%（61.3% vs 44.0%;P0.05）.Conclusion A higher COHb level often promises serious condition for carbon monoxide-poisoned patients.