Disparity in HLA-DR typing and mixed lymphocyte culture reactivity |
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Authors: | R A Smith R Belcher |
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Affiliation: | Department of Microbiology and Immunology, College of Science and Mathematics, School of Medicine, Wright State University, Dayton, OH 45435. |
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Abstract: | Prospective HLA-DR matching has been shown to enhance renal graft survival. It has also been demonstrated that the major stimuli in the one-way mixed lymphocyte culture reaction (MLR) are the DR rather than DQ class II histocompatibility antigens. A two antigen DR match between the potential recipient and donor is usually associated with a negative MLR. The findings of two family studies are reported in which HLA-DR identity between the potential recipient and donors did not correlate with the MLR reactivity. These findings further strengthen the need for performing the MLR in conjunction with DR/DQ typing since splits have been described for some of the DR antigens which may not be detected using the currently available commercial typing trays. |
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