氟西汀片治疗灼口综合征临床疗效

目的:观察盐酸氟西汀片治疗灼口综合征(BMS)的临床疗效.方法:选择BMS患者30例,随机分为治疗组15例,口服氟西汀片10mg·d-1,qd,连用6周;对照组15例,口服复合维生素B每日1片,连用6周.治疗前后记录患者疼痛程度和发生频率.结果:治疗组痊愈4例,显效6例,有效3例,总有效率86.6%,与对照组总有效率33.3%相比,差异有显著性(P＜0.01).结论:将灼口综合征视为心身性疾病,应用抗抑郁类药物氟西汀片治疗,疗效显著.然而,停药后的复发情况有待进一步观察.

The efficacy of fluoxetine tablets in treatment of burning mouth syndrome

Objective: To observe the efficacy of fluoxetine tablets in treatment of burning mouth syndrome. Methods: 30 patients with burning mouth syndrome were randomly and equally divided to receive fluoxetine tablets in a dose of 10mg daily for 6 consecutive weeks or compound Vit B tablets in a dose of 1 tablet daily for 6 consecutive weeks. Results: A total effective rate of 86. 6% for the active group and 33.3% for the control group were obtained. There was significant difference between 2 groups (P<0.01). Conclusion:Fluoxetine tablets are highly effective in treatment of burning mouth syndrome but the recurrence after drug therapy remains to be observed.