| 原发灶18F-FDG PET/CT肿瘤代谢体积与晚期非小细胞肺癌患者预后的相关性研究 |
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| 引用本文： | 赵芬,张秀丽,孙晓蓉,霍宗伟,郑劲松,付政,马莉,赵书强,滕学鹏,杨国仁. 原发灶18F-FDG PET/CT肿瘤代谢体积与晚期非小细胞肺癌患者预后的相关性研究[J]. 中国医学影像学杂志, 2011, 19(4): 252-256. DOI: 10.3969/j.issn.1005-5185.2011.04.004 |
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| 作者姓名： | 赵芬 张秀丽 孙晓蓉 霍宗伟 郑劲松 付政 马莉 赵书强 滕学鹏 杨国仁 |
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| 作者单位： | 1. 山东省肿瘤医院PET-CT中心;山东省放射肿瘤学重点实验室,山东济南,250117
2. 山东省肿瘤医院内六科,山东济南,250117 |
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| 基金项目： | 本课题受山东省自然科学基金 |
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| 摘 要： | 目的探讨晚期非小细胞肺癌(NSCLC)原发灶18F-FDG PET/CT肿瘤代谢活性体积(MTV)与预后的关系。资料与方法回顾性分析治疗前行PET/CT检查的110例均经病理或细胞学证实的Ⅲ、Ⅳ期NSCLC患者,所有患者均接受同步放、化综合治疗,治疗后随访2年以上,并用Kaplan-Meier法、Log-rank检验及Cox比例风险模型分析MTV及标准摄取值(SUV)与预后的关系,ROC曲线比较MTV与SUVmax预测患者预后的能力。结果全组患者2年总生存率为20.9%,ROC曲线分析显示,MTV与SUV预测预后的曲线下面积分别为0.649和0.523;MTV≤33.8cm3与MTV>33.8cm3患者2年生存率分别为27.6%和5.9%,差异具有统计学意义(P<0.05);单因素及多因素分析均显示,2年生存率与MTV、临床分期、病理类型有关(P<0.05)。结论晚期NSCLC原发灶MTV与患者的预后相关,MTV较大者,患者的生存期较短。
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| 关 键 词： | 肺肿瘤 正电子发射断层显像术 体层摄影术,X线计算机 氟脱氧葡萄糖F18 预后 |
Association between Metabolic Tumor Volume from 18F-FDG PET/CT and Prognosis in Patients with Advanced NSCLC |
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| ZHAO Fen,ZHANG Xiuli,SUN Xiaorong,HUO Zongwei,ZHENG Jinsong,FU Zheng,MA Li,ZHAO Shuqiang,TENG Xuepeng,YANG Guoren. Association between Metabolic Tumor Volume from 18F-FDG PET/CT and Prognosis in Patients with Advanced NSCLC[J]. Chinese Journal of Medical Imaging, 2011, 19(4): 252-256. DOI: 10.3969/j.issn.1005-5185.2011.04.004 |
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| Authors: | ZHAO Fen ZHANG Xiuli SUN Xiaorong HUO Zongwei ZHENG Jinsong FU Zheng MA Li ZHAO Shuqiang TENG Xuepeng YANG Guoren |
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| Affiliation: | ZHAO Fen ZHANG Xiuli SUN Xiaorong HUO Zongwei ZHENG Jinsong FU Zheng MA Li ZHAO Shuqiang TENG Xuepeng YANG Guoren PET-CT Center of Shandong Tumor Hospital,Shangdong Radiology FAT LAB,Jinan,Shandong 250117 |
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| Abstract: | Purpose To evaluate the correlation between the metabolic tumor volume(MTV) of 18-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) of primary lesions and the prognosis in patients with advanced non small cell lung cancer(NSCLC).Materials and methods One hundred and ten patients with advanced NSCLC underwent 18F-FDG PET/CT scan were recruited in this study consecutively from January 2005 to December 2007.All the patients developed NSCLC with pathological stage on III or IV ... |
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| Keywords: | Lung neoplasms Positron-emission tomography Tomography X-ray computed Fluorodeoxyglucose F18 Prognosis |
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