| 喹诺酮类药物无菌检查中Mg2+的应用研究 |
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| 引用本文： | 裴小龙,黎隽,杨晓莉,周志云.喹诺酮类药物无菌检查中Mg2+的应用研究[J].中国药业,2011,20(1):28-29. |
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| 作者姓名： | 裴小龙 黎隽 杨晓莉 周志云 |
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| 作者单位： | 1. 陕西省食品药品检验所,陕西,西安,710061
2. 陕西省医疗器械检测中心,陕西,西安,710061 |
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| 摘 要： | 目的研究Mg2+在喹诺酮类药物无菌检查法中的应用。方法在培养基中加入不同浓度的Mg2+,观察不同方法中6种阳性对照菌的生长情况。结果 Mg2+浓度对消除喹诺酮类药物的抑菌性有不同的影响。结论 Mg2+浓度为0.2 mol/L的培养基能有效消除喹诺酮类药物的抑菌性。
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| 关 键 词： | 喹诺酮类药物 抑菌作用 无菌检查法 镁离子 |
Study on Application of Mg2+ in Sterility Test of Quinolones |
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| Pei Xiaolong,Li Jun,Yang Xiaoli,Zhou Zhiyun.Study on Application of Mg2+ in Sterility Test of Quinolones[J].China Pharmaceuticals,2011,20(1):28-29. |
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| Authors: | Pei Xiaolong Li Jun Yang Xiaoli Zhou Zhiyun |
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| Institution: | Pei Xiaolong1,Li Jun2,Yang Xiaoli1,Zhou Zhiyun1(1.Shaanxi Provincial Institute of Food and Drug Control,Xi'an,Shaanxi,China 710061,2.Shaanxi Center for Medical Devices Testing,China 710061) |
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| Abstract: | Objective To study the application of Mg2+in the sterility test of quinolones.Methods The growth of 6 positive control bacteria was observed after adding different concentrations of Mg2+into culture medium.Results According to the results,the antimicrobial activity of quinolones was affected by the concentration of Mg2+in some extent.Conclusion The culture medium with 0.2 mol/L Mg2+could effectively eliminate the antimicrobial effect of quinolones. |
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| Keywords: | quinolones antimicrobial effect sterility test Mg2 |
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