| 高效液相色谱法测定醋酸肤轻松搽剂中醋酸肤轻松含量 |
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| 引用本文： | 蔡果,申国庆,龚春燕. 高效液相色谱法测定醋酸肤轻松搽剂中醋酸肤轻松含量[J]. 中国药业, 2011, 20(5): 30-31 |
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| 作者姓名： | 蔡果 申国庆 龚春燕 |
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| 作者单位： | 中国医学科学院中国协和医科大学皮肤病研究所,江苏,南京,210042 |
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| 摘 要： | 目的建立醋酸肤轻松搽剂中醋酸肤轻松含量测定的高效液相色谱法。方法色谱柱为C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-水(70:30),检测波长为240 nm,流速为1.0 mL/min。结果醋酸肤轻松质量浓度在6.20～31.00μg/mL范围内与峰面积线性关系良好(r=0.9999),平均加样回收率为99.18%,RSD为0.33%(n=6)。结论所建立的方法简便、快捷、结果准确,适用于该制剂的质量控制。
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| 关 键 词： | 高效液相色谱法 醋酸肤轻松 搽剂 |
Determination of Main Component in Fluocinonide Acetonide Liniment by HPLC |
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| Cai Guo,Shen Guoqing,Gong Chunyan. Determination of Main Component in Fluocinonide Acetonide Liniment by HPLC[J]. China Pharmaceuticals, 2011, 20(5): 30-31 |
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| Authors: | Cai Guo Shen Guoqing Gong Chunyan |
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| Affiliation: | Cai Guo,Shen Guoqing,Gong Chunyan(Research Institute of Dermatology,Chinese Academy of Medical Science,Peking Union Medical College,Nanjing,Jiangsu,China 210042) |
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| Abstract: | Objective To establish a simple and sensitive HPLC method for the content determination of fluocinonide acetonide in Fluocinonide Acetonide Liniment.Methods The Symmetry C18 coloumn（250 mm×4.6 mm,5 μm） was used with methanol-H2O（70 ∶30） as the mobile phase.The flow rate was 1.0 mL/min and the detection wavelength was 240 nm.Results The good linearity was obtained over the range of 6.20-31.00 μg/mL（r=0.999 9） for fluocinonide acetonide.The average recovery rate was 99.18%,RSD was 0.33%（n=6）.Conclusion The established method is simple,rapid and accurate,which is suitable for the quality control of this preparation. |
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| Keywords: | HPLC fluocinonide acetonide liniment |
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