| 伏隔核电刺激对大鼠吗啡条件性位置偏爱重现的影响 |
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| 引用本文： | 刘鸿宇,崔建梅,王晨光,张磊,金捷. 伏隔核电刺激对大鼠吗啡条件性位置偏爱重现的影响[J]. 中国药物依赖性杂志, 2011, 20(2): 93-96 |
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| 作者姓名： | 刘鸿宇 崔建梅 王晨光 张磊 金捷 |
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| 作者单位： | 1. 中北大学生理学实验室,太原,030051
2. 西安交通大学医学院医学电子工程研究所,生物医学信息工程教育部重点实验室,西安,710061 |
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| 摘 要： | 目的:为寻找防治药物依赖新方法,本文以大鼠条件性位置偏爱(CPP)为模型,探讨伏隔核电刺激对阿片类物质奖赏效应的影响.方法:20只成年大鼠分为两组:深部脑刺激(deep brain stimulation,DBS)组和假DBS组.用立体定位手术将DBS装置的电极部分植入一侧伏隔核(NAc)核心部,与脉冲发生器(IPG)...
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| 关 键 词： | 深部脑刺激 伏隔核 吗啡 条件性位置偏爱 |
EFFECTS OF DEEP BRAIN STIMULATION IN NUCLEUS ACCUMBENS ON THE REINSTATEMENT OF MORPHINE CONDITIONED PLACE PREFERENCE IN RATS |
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| LIU Hongyu,CUI Jianmei,WANG Chenguang,ZHANG Lei,JIN Jie. EFFECTS OF DEEP BRAIN STIMULATION IN NUCLEUS ACCUMBENS ON THE REINSTATEMENT OF MORPHINE CONDITIONED PLACE PREFERENCE IN RATS[J]. Chinese Journal of Drug Dependence, 2011, 20(2): 93-96 |
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| Authors: | LIU Hongyu CUI Jianmei WANG Chenguang ZHANG Lei JIN Jie |
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| Affiliation: | LIU Hongyu1,CUI Jianmei1,WANG Chenguang1,ZHANG Lei1,JIN Jie2 1(Physiological Laboratory,North University of China,Taiyuan,030051,China) 2(Institute of Medical Electronics in Medical School,Key Laboratory of Biomedical Information Engineering,Ministry of Education,Xi'an Jiaotong University,Xi'an 710061,China) |
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| Abstract: | Objective: To explore a novel method for the treatment of drug dependence,we investigated the effect of deep brain stimulation(DBS)of nucleus accumbens(NAc)on the rewarding effects of opiates,using morphine conditioned place preference(CPP)in rats.Methods:Twenty adult rats were divided into two groups,DBS group and sham DBS group.The DBS electrode was stereotaxically implanted into the core of unilateral NAc,connected to an implantable pulse generator(IPG),and they were fixed to the rat skull.One week later... |
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| Keywords: | deep brain stimulation nucleus accumbens morphine conditioned place preference |
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