| 格列美脲和那格列奈治疗2型糖尿病的疗效比较 |
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| 引用本文： | 吴冀川,易红,龙恩武,袁浩宇.格列美脲和那格列奈治疗2型糖尿病的疗效比较[J].中国药业,2011,20(1):68-69. |
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| 作者姓名： | 吴冀川 易红 龙恩武 袁浩宇 |
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| 作者单位： | 1. 四川省医学科学院·四川省人民医院,四川,成都,610072
2. 核工业四一六医院,四川,成都,610051 |
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| 摘 要： | 目的 评价那格列奈和格列美脲治疗2型糖尿病的疗效及安全性,为临床提供用药参考.方法 将48例2型糖尿病患者随机均分为那格列奈组和格列美脲组,疗程为12周.观察两组血糖、胰岛素、糖化血红蛋白(HbA1c)等变化及不良反应.结果 两组患者治疗后空腹血糖、餐后2 h血糖和HbA1c均明显下降(P＜0.05),两药降低空腹血糖的幅度无统计学意叉,而那格列奈降低餐后2 h血糖和HbA1c的疗效优于格列美脲(P＜0.05),那格列奈组餐后2 h血浆胰岛素浓度高于格列美脲(P＜0.05).结论 那格列奈和格列美脲均能使空腹血糖明显降低,但那格列奈控制餐后2 h血糖和降低HbA1c的效果优于格列美脲.两药均较安全.
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| 关 键 词： | 格列美脲 那格列奈 2型糖尿病 |
Comparison of Clinical Effects of Glimepiride and Nateglihide in Treating Type 2 Diabetes Mellitus |
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| Wu Jichuan,Yi Hong,Long Enwu,Yuan Haoyu.Comparison of Clinical Effects of Glimepiride and Nateglihide in Treating Type 2 Diabetes Mellitus[J].China Pharmaceuticals,2011,20(1):68-69. |
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| Authors: | Wu Jichuan Yi Hong Long Enwu Yuan Haoyu |
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| Institution: | Wu Jichuan1,Yi Hong2,Long Enwu1,Yuan Haoyu2(1.Sichuan Provincial People's Hospital,Sichuan Academy of Medical Science,Chengdu,Sichuan,China 610072,2.Nuclear Industry 416 Hospital,China 610051) |
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| Abstract: | Objective To explore the effect and safety of nateglinide and glimepiride in treating type 2 diabetes to provide reference for clinical drug use.Methods Forty-eight patients with type 2 diabetes were divided into two groups randomly,the nateglinide group(n=24)and the glimepiride group(n=24).The age,sex and clinical symptoms of two groups were matched.The treatment period was 12 weeks.The changes and adverse reactions of fasting blood glucose(FBG),postprandial blood glucose(PBG),insulin,HbA1C,etc.and adverse... |
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| Keywords: | glimepiride nateglihide type 2 diabetes mellitus |
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