| 线栓法制备大鼠脑缺血再灌注模型的改进 |
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| 引用本文： | 王炳高,袁新颜,王守彪,郭云良,李永刚. 线栓法制备大鼠脑缺血再灌注模型的改进[J]. 青岛大学医学院学报, 2005, 41(1): 73-74 |
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| 作者姓名： | 王炳高 袁新颜 王守彪 郭云良 李永刚 |
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| 作者单位： | 青岛大学医学院第二附属医院乳腺外科,山东,青岛,266042;青岛大学医学院人体解剖学教研室 |
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| 基金项目： | 山东省自然科学基金资助项目(Q97C01125) |
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| 摘 要： | ①目的建立一种理想大鼠大脑中动脉缺血(MACO)再灌注动物模型。②方法成年健康雄性Witar大鼠110只，分别应用Zea Longa法、刘亢丁法和改良法建立MACO模型各35只，假手术组5只。利用行为学测试、四氮唑(TTC)染色对各种方法进行评价。③结果改良法的手术时间短、动物死亡率低、神经缺失体征明显、梗死灶固定。④结论改良线栓法是制备MACO再灌注动物模型的较为理想的方法。
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| 关 键 词： | 动物模型 脑缺血 再灌注 大鼠 |
| 文章编号： | 1672-4488(2005)01-0073-02 |
| 修稿时间： | 2004-07-28 |
AN IMPROVEMENT OF THE MODEL OF FOCAL CEREBRAL ISCHEMIA AND REPERFUSION WITH LINE OCCLUSSION IN RATS |
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| WANG Bing-gao,YUAN Xin-yan,WANG Shou-biao,et al. AN IMPROVEMENT OF THE MODEL OF FOCAL CEREBRAL ISCHEMIA AND REPERFUSION WITH LINE OCCLUSSION IN RATS[J]. Acta Academiae Medicinae Qingdao Universitatis, 2005, 41(1): 73-74 |
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| Authors: | WANG Bing-gao YUAN Xin-yan WANG Shou-biao et al |
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| Abstract: | Objective To establish an ideal animal model of reperfusion of ischemia of middle cerebral artery in rats. Methods The models were established with methods of Zea Longa, Liu Kangding, and modified methods in 35 adult Wistar rats, respectively. Another five were sham-operated. The results were evaluated with behavior tests and TTC staining. Results Short operation time, low death rate, obvious signs of nerve deletion, and stable location of infarction were achieved with the modified method. Conclusion The modified line occlusion is an ideal method for establishing the model of this type in rats. |
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| Keywords: | animal model cerebral ischemia reperfusion rats |
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