外用糖皮质激素接触过敏78例分析

目的 探讨外用糖皮质激素的过敏情况。方法 选择适宜外用糖皮质激素治疗但疗效欠佳的患者1822例，按照国际接触性皮炎研究组的规定做糖皮质激素皮肤斑贴试验。结果 1822例患者中，78例斑贴试验阳性，占4.28%；其中男33例，女45例；取掉斑试物后96 ~ 168 h判读结果阳性33例，占42.31%；氢化可的松丁酸酯（阳性28例）、 地塞米松磷酸钠盐（阳性25例）、醋酸曲安奈德（阳性17例）等发生过敏较多。74例被检阳性糖皮质激素与临床使用的药物存在关联。结论 外用糖皮质激素接触过敏并不罕见，在外用糖皮质激素治疗皮肤炎症时，宜注意糖皮质激素过敏问题。

An analysis On 78 cases of contact allergy to topical corticosteroids

Objective To update the knowledge of contact allergy to topical corticosteroids.Methods A total Of 1,822 patients,who Sufiered from inflammatory skin disorders but did not respond well to topical corticosteroids,were enrolled into this study.Patch test was performed on these subjects with corticosteroid allergens,following the standardized rocedures ecommended by the International Contact Dermatitis Research Group(ICDRG).Results Of all patients,78(4.28%)had positive patch test.Among the 78 patients,33 were males,45 females,and most were young or middle-aged.During 96-168 hours after the removal of patches,positive results Were observed in 42.31%(33/78)of the patients.Twenty eight patients had anaphy lactic reaction induced by hydrocortisone butyrate,25 by dexamethasone sodium phosphate,and 17 by triam cinolone acetonide.A correlation Between sensitizing glucocorticoids detected by patch testing and adminis trated drugs in clinic was found in 74 cases.Conclusions Contact allergy caused by topical corticosteroids is not rare,and more attention should be paid to this issue in the treatment of inflammatory skin disorders.