Influence of hyperglycemia on Ca2+-Mg2+-ATPase of red blood cells from diabetic patients

Summary The influence of hyperglycemia on calmodulin-stimulated Ca²⁺-Mg²⁺-ATPase activity was studied in 20 diabetic subjects. A clear inverse relationship between short-term hyperglycemia as well as chronic hyperglycemia and calmodulin-stimulated Ca²⁺-Mg²⁺-ATPase activity could be demonstrated. Such a relationship could not be shown for basal enzyme activity.Abbreviations ATPase Adenosine 5-triphosphatase - Pi Inorganic phosphate - TBA 2-Thiobarbituric acidThis work was supported by the Bundesminister für Jugend, Frauen, Familie und Gesundheit, Bonn, and the Minister für Wissenschaft und Forschung des Landes Nordrhein-Westfalen, Düsseldorf, Federal Republic of GermanySome results are part of the thesis of J. Beeker