| 鼻咽癌病人端粒酶表达的研究 |
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| 引用本文： | 文忠,唐发清.鼻咽癌病人端粒酶表达的研究[J].中国耳鼻咽喉颅底外科杂志,1998,4(4):215-218. |
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| 作者姓名： | 文忠 唐发清 |
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| 作者单位： | [1]湖南医科大学附属湘雅医院耳鼻咽喉科 [2]湖南医科大学附属湘雅医院中心实验室 |
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| 基金项目： | 湖南省科委基金,国家自然科学基金 |
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| 摘 要： | 目的：研究端粒酶（ＴＬＭＡ）在鼻咽癌（ＮＰＣ）中的表达。方法：采用ＴＲＡＰ ＰＣＲ ＥＬＩＳＡ法探讨１８例ＮＰＣ，２例放疗后ＮＰＣ，４例癌旁组织及４例慢性鼻咽炎鼻咽部活检组织中ＴＬＭＡ表达。结果：１８例ＮＰＣ ＴＬＭＡ阳性率为８８．９％。４例癌旁组织阳性率为７５．０％，慢性鼻咽炎全部为阴性。１例复发性ＮＰＣ为阳性，１例疗后未复发为阴性。ＴＬＭＡ表达与ＮＰＣ分期、颈淋巴结转移似无明显关系。结论：ＴＬ
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| 关 键 词： | 鼻咽肿瘤 端粒酶 TLMA |
TELOMERASE EXPRESSION IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA |
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| Wen Zhong,Xiao Jianyun,Tang Faqing,et al.TELOMERASE EXPRESSION IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA[J].Chinese Journal of Otorhinolaryngology-skull Base Surgery,1998,4(4):215-218. |
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| Authors: | Wen Zhong Xiao Jianyun Tang Faqing |
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| Institution: | Wen Zhong,Xiao Jianyun,Tang Faqing,et al Department of ENT,Xiangya Hospital,Hunan Medical University,Changsha,410008 |
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| Abstract: | Objective:To study the telomerase expression in NPC.Methods:The telomerase expression was detected from 18 cases of NPC, 2 cases of post-radiotherapy NPC,4 cases of epithelium adjacent to NPC and 4 cases of chronic nasopharyngitis with TRAP PCR ELISA kit.Results:The telomerase activity in the 18 cases of NPC and the 4 cases of epithelium adjacent to NPC reached 88.9% and 75.0%,respectively.None in the 4 cases of chronic nasopharyngitis was positive.It was also found that there was a higher telomerase expression in 1 case of recurrent NPC after radiotherapy.In addition, there seemed to be no obvious relationship between TLMA activity and stage,lymph node involvement and histological classification.Conclusion:There is a high telomerase expression in NPC and in epithelium adjacent to NPC. |
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| Keywords: | Carcinoma nasopharyngeal neoplasms Telomerase |
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