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Preparation, dissolution and characterization of albendazole solid dispersions
Authors:Susana Torrado ,Santiago Torrado,Juan José   Torrado,Rafael Cadó  rniga
Affiliation:

aDepartamento de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Madrid, Spain

bUniversidad Complutense de Madrid, Madrid 28040, Spain

Abstract:In this study, solid dispersion systems of the sparingly water soluble drug, albendazole (ABZ), were mixed with varying concentrations of polyvinylpyrrolidone (PVP K 12) in an attempt to improve the solubility and dissolution rate of ABZ. Physical characteristics were investigated by Powder X-ray diffraction. As expected, the albendazole dissolution rate, expressed as the dissolution efficiency, and also the solubility coefficient were increased when albendazole was mixed with PVP. An increase in the concentration of the polymer in the solid dispersion produced an increase in both parameters. The powder X-ray diffraction patterns showed that the solid dispersion presented an amorphous form of albendazole in this coprecipitate system.
Keywords:Albendazole   Polyvinylpyrrolidone   Solid dispersion   Powder X-ray diffraction   Dissolution rate   Drug-carrier
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