窄谱中波紫外线照射与308nm准分子光分别联合阿维A胶囊对寻常型银屑病的疗效比较

目的比较窄谱中波紫外线照射与308 nm准分子光分别联合阿维A胶囊对寻常型银屑病的疗效。方法根据治疗方式的不同将130例寻常型银屑病患者分为A组与B组,各65例,A组予以窄谱中波紫外线照射联合维A胶囊治疗,B组予以308 nm准分子光联合维A胶囊治疗。比较两组的临床疗效、治疗前、后SCORAD、VAS、PASI、SAS、SDS评分及不良反应发生情况。结果 B组的治疗总有效率显著高于A组(P<0.05)。治疗后,两组的SCORAD、VAS和PASI评分均降低,差异具有统计学意义(P<0.05);治疗后,B组的SCORAD、VAS和PASI评分均显著低于A组,差异具有统计学意义(P<0.05)。治疗后,两组的SAS及SDS评分均降低,差异具有统计学意义(P<0.05);治疗后,B组的SAS及SDS评分略低于A组,但差异不具有统计学意义(P>0.05)。B组的不良反应总发生率显著低于A组(P<0.05)。结论 308 nm准分子光联合阿维A胶囊治疗寻常型银屑病更为安全有效,可提高患者生活质量,减少不良反应,值得推广应用。

Comparison of efficacy of narrow-band ultraviolet irradiation or 308 nm excimer light combined with acitretin capsule on psoriasis vulgaris

Objective To compare the efficacy of narrow-band ultraviolet irradiation or 308 nm excimer light combined with acitretin capsule on psoriasis vulgaris.Methods A total of 130 patients with psoriasis vulgaris were divided into group A and group B according to different treatment methods,with 65 cases in each group.The group A was treated with narrow-band ultraviolet irradiation combined with acitretin capsule,and the group B was treated with 308 nm excimer light and acitretin capsule.The clinical efficacy,scores of SCORAD,VAS,PASI,SAS,SDS before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the group B was significantly higher than that of the group A(P<0.05).After treatment,the scores of SCORAD,VAS and PASI in the two groups decreased,the differences were statistically significant(P<0.05);after treatment,the scores of SCORAD,YAS and PASI in the group B were significantly lower than those in the group A,the differences were statistically significant(P<0.05).After treatment,the scores of SAS and SDS in the two groups decreased,and the differences were statistically significant(P<0.05);after treatment,the scores of SAS and SDS in the group B were slightly lower than those in the group A,but the differences were not statistically significant(P>0.05).The total incidence of adverse reactions in the group B was significantly lower than that in the group A(P<0.05).Conclusion 308 nm excimer light combined with acitretin capsule is more safe and effective in the treatment of psoriasis vulgaris.It can improve the quality of life of patients,reduce adverse reactions,which is worth popularizing and applying.