Effects of trimetazidine in acute pancreatitis induced by L-arginine |
| |
Authors: | Akan Yenicerioglu Ziya Cetinkaya Mustafa Girgin Bilal Ustundag Ibrahim Hanefi Ozercan Refik Ayten Burhan Hakan Kanat |
| |
Institution: | *Department of General Surgery, Karakocan City Hospital, Elazig, Turkey;†Department of General Surgery, Firat University School of Medicine, Elazig, Turkey;‡Department of Biochemistry, Firat University School of Medicine, Elazig, Turkey;§Department of Pathology, Firat University School of Medicine, Elazig, Turkey;¶Department of General Surgery, Training and Research Hospital, Elazig, Turkey |
| |
Abstract: | BackgroundIn acute pancreatitis, oxygen free radicals (OFRs) and cytokines have been shown to play a role in the failure of pancreatic microcirculation and the development of local tissue damage. We studied the effects of trimetazidine (TMZ), a potent antioxidant and anti-ischemic agent, on acute pancreatitis.MethodsRats were randomized into 3 groups: a control group (n = 15), a study group (n = 15) in which acute pancreatitis was induced with with L-arginine, and a treatment group (n = 15) in which pancreatitis was induced and treated with TMZ intraperitoneally. The rats were followed for 24 hours. At the 24th hour we determined serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase, lactate dehydrogenase (LDH), interleukin 1-β (IL-1β), interleukin 6 (IL-6) and tumour necrosis factor-α (TNF-α), and the pancreatic tissues were analyzed histopathologically.ResultsThe AST (p < 0.001), ALT (p < 0.01), amylase (p < 0.001), LDH (p < 0.01), TNF-α (p < 0.01), IL-1β (p < 0.001) and IL-6 (p < 0.001) levels, and pancreatic tissue edema (p < 0.01), hemorrhage (p < 0.05), acinar cell necrosis (p < 0.001) and level of perivascular inflammation (p < 0.01), were significantly lower in the treatment group than the study group.ConclusionTrimetazidine markedly decreases biochemical and histopathologic changes during the early stages of acute pancreatitis, thus preserving the pancreas histologically. |
| |
Keywords: | |
|
|