Activation of Nrf2 signaling by 4-octyl itaconate attenuates the cartilaginous endplate degeneration by inhibiting E3 ubiquitin ligase ZNF598 |
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| Affiliation: | 2. Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3, Qingchun Road East, Hangzhou, 310016, PR China;3. Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, No. 3, Qingchun Road East, Hangzhou, 310016, PR China;4. Department of Orthopedics Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41, Northwest Street, Ningbo, 315010, Zhejiang, PR China;6. Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, SAR, PR China;2. Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA;3. Thurston Arthritis Research Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;4. Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People''s Republic of China;2. Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University, Maastricht, the Netherlands;3. Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands;4. Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands;2. Department of Biomedical Engineering, Duke University, Durham, NC, USA;3. Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA;4. Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA;6. Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA;5. Department of Radiology, Duke University School of Medicine, Durham, NC, USA;11. Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA;2. Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA;3. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA;4. Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA;6. Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, OH, USA;5. Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA;11. Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA;12. Arthritis Foundation, GA, USA;8. Siemens Medical Solution Inc., USA;10. GE Healthcare, Waukesha, WI, USA;9. Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Department of Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, University Medical Center Göttingen, Göttingen, Germany;3. University of Göttingen Johann-Friedrich-Blumenbach-Institute for Zoology & Anthropology, Department of Historical Anthropology and Human Ecology, Göttingen, Germany;2. Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands;3. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands;4. Dept. Orthopaedics, Leiden University Medical Center, Leiden, the Netherlands |
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| Abstract: | |
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| Keywords: | Intervertebral disc degeneration Nrf2 4-Octyl itaconate Cartilaginous endplate Inflammation LBP" },{" #name" :" keyword" ," $" :{" id" :" pc_fpJmq1x8Rr" }," $$" :[{" #name" :" text" ," _" :" low back pain CEP" },{" #name" :" keyword" ," $" :{" id" :" pc_e2y87Ob5cr" }," $$" :[{" #name" :" text" ," _" :" cartilaginous endplate NP" },{" #name" :" keyword" ," $" :{" id" :" pc_z0Q3zM6Ukm" }," $$" :[{" #name" :" text" ," _" :" nucleus pulposus IVDD" },{" #name" :" keyword" ," $" :{" id" :" pc_OXHzuXopiT" }," $$" :[{" #name" :" text" ," _" :" Intervertebral disc degeneration MMP" },{" #name" :" keyword" ," $" :{" id" :" pc_ye4x4a0IgA" }," $$" :[{" #name" :" text" ," _" :" matrix metalloprotease ECM" },{" #name" :" keyword" ," $" :{" id" :" pc_z2QPfBGyMr" }," $$" :[{" #name" :" text" ," _" :" extracellular matrix NFE2L2" },{" #name" :" keyword" ," $" :{" id" :" pc_IcFM2eBNJy" }," $$" :[{" #name" :" text" ," _" :" nuclear factor E2-related factor 2 4OI" },{" #name" :" keyword" ," $" :{" id" :" pc_BNBVhI4Amh" }," $$" :[{" #name" :" text" ," _" :" 4-octyl itaconate MitoSOX" },{" #name" :" keyword" ," $" :{" id" :" pc_Yrs5hmOdIa" }," $$" :[{" #name" :" text" ," _" :" mitochondrial superoxide IL-1β" },{" #name" :" keyword" ," $" :{" id" :" pc_dKLY75VLDR" }," $$" :[{" #name" :" text" ," _" :" interleukin 1β TNF-α" },{" #name" :" keyword" ," $" :{" id" :" pc_Tykmnq2DhG" }," $$" :[{" #name" :" text" ," _" :" tumor necrosis factor α |
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