乙酸钙的纯化工艺 |
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引用本文: | 钱如贵,袁玲玲,丁丽娜,李凤,陈龙芳.乙酸钙的纯化工艺[J].中国医药工业杂志,2020(2):270-275. |
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作者姓名: | 钱如贵 袁玲玲 丁丽娜 李凤 陈龙芳 |
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作者单位: | 昆明邦宇制药有限公司 |
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摘 要: | 碳酸钙和冰乙酸在水中反应得到乙酸钙溶液,室温下加入约2.5倍体积的95%乙醇,静置2~4 h,以300目滤布挤压过滤,滤液浓缩后重复操作1次,合并2次所得乙酸钙,80℃热风循环干燥3 h,即得乙酸钙纯品,收率可达82%以上。本工艺产品中镁含量大大降低,质量指标符合美国药典(USP40)要求。
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关 键 词: | 碳酸钙 乙酸钙 乙醇沉淀 纯化 |
Purification Process for Calcium Acetate |
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Authors: | QIAN Rugui YUAN Lingling DING Lina LI Feng CHEN Longfang |
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Institution: | (Kunming Bangyu Pharmaceutial Co.,Ltd.,Kunming 650211) |
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Abstract: | Calcium acetate solution was prepared from calcium carbonate and glacial acetic acid in water. Adding about 2.5 times of the volume of 95% ethanol as much as the above solution at room temperature, then the mixture was settled for 2-4 h and filtered with 300 mesh filtration fabric. After concentration, the above operation was repeated once. The precipitate combined was dried at 80 ℃ for 3 h to obtain the purified calcium acetate, and the total yield was above 82%. The magnesium content in the purified calcium acetate was significantly decreased. It was concluded that the final product was consistent with the quality specification of calcium acetate in US pharmacopoeia(USP40). |
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Keywords: | calcium carbonate calcium acetate ethanol precipitation purification |
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