Association of parental cardiovascular risk factors with offspring type 1 diabetes mellitus insulin sensitivity |
| |
| Institution: | 1. Faculty of Medicine and Life Sciences, University of Tampere, Arvo Ylpön katu 34, 33520, Tampere, Finland;2. Department of Surgery, Kanta-Häme Central Hospital, Ahvenistontie 20, 13530 Hämeenlinna, Finland;3. Department of Musculoskeletal Surgery and Diseases, Tampere University Hospital, Elämänaukio 2, 33521 Tampere, Finland;4. Tays Research Services, Tampere University Hospital, Arvo Ylpön katu 6, 33521 Tampere, Finland;5. Faculty of Social Sciences, Health Sciences, Tampere University, Arvo Ylpön katu 34, 33520 Tampere, Finland;1. Department of Cardiovascular Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou 510120, China;2. Guangdong Provincial Key Laboratory of Arrhythmia and Electrophysiology, Gungzhou 510120, China;3. Guangzhou Key Laboratory of Molecular Mechanism and Translation in Major Cardiovascular Disease, Guangzhou 510120, China;4. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China;5. Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou 510120, China;1. MGH Neuroscience Center, Department of Neurology, Harvard Medical School, Boston, MA, United States of America;2. Department of Neurology, University of Colorado Hospital, Aurora, CD, United States of America;3. Department of Pathology, Massachusetts General Hospital, Boston, MA, United States of America;4. Division of Neuromuscular Research at Beth Israel Deaconess Medical Center, United States of America;5. Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland;1. Department of Ophthalmology, Research Unit of Clinical Medicine and Medical Research Centre, University of Oulu, Finland;2. Oulu University Hospital, Oulu, Finland;3. Research Service Unit, Oulu, Finland;4. The Research Unit of Surgery, Anaesthesia and Intensive Care, Oulu University Hospital and University of Oulu, Oulu, Finland |
| |
| Abstract: | AimThis study aimed to determine whether the insulin resistance (IR) and lipid profiles in Type 1 Diabetes (T1D) offspring are associated with IR and other cardiovascular risk factors in their parents.MethodsThis study included 99 T1D patients (19.6 ± 4.0 yrs.), 85 mothers and 60 fathers. Parents' IR was assessed by HOMA-IR, and the insulin sensitivity in T1D patients was assessed by the estimated Glucose Disposal Rate (eGDR).ResultsThe eGDR in the T1D offspring was negatively related to age (p = 0.023), weight (p = 0.004), LDL (p = 0.026), and microalbuminuria (p = 0.019). Maternal Type 2 Diabetes (p < 0.001) and HOMA-IR (p = 0.029) were negatively related to eGDR in their T1D offspring. The maternal HOMA-IR and the proband's eGDR were positively (p = 0.012) and negatively (p = 0.042) associated with the birth weight of the T1D offspring, respectively. We didn't find an association with the fathers' profiles.ConclusionsIn a cohort of offspring with T1D the insulin sensitivity was related to the IR, lipid profile, and the presence of T2D only in their mothers. Precocious screening and treatment of these risk factors beyond glycemic control will benefit T1D with this background. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
