Cow milk protein antigens and antibodies in serum of premature infants during the first 10 days of life |
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| Authors: | G Müller I Bernsau W Müller E Weissbarth-Riedel J Natzschka C H Rieger |
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| Affiliation: | 1. Section of Immunology and Chest Disease, Zentrum für Kinderheilkunde, Philipps-University, Marburg, West Germany;2. Hannover''sche Kinderheilanstalt, West Germany;3. Zentrum für Kinderheilkunde und Klinische Genetik der Medizinischen Hochschule, Hannover, West Germany;1. Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China;2. Medical School of Chinese PLA & Department of Clinical Laboratory Medicine, Chinese People’s Liberation Army General Hospital, Beijing, China;3. Department of Gastroenterology, Peking University People’s Hospital, Beijing, China;1. Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;2. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates;3. Meakins-Christie Laboratories, Research Institute of the McGill University Healthy Center, McGill University, Montreal, QC, Canada;4. Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;5. Department of Biomedical Engineering, College of Engineering, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;6. Department of Genetics and Molecular Biology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;7. Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;8. Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Saudi Arabia;1. VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium;2. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;3. Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium;4. Laboratory of Gene Therapy, Department of Nutrition, Genetics and Ethology, Ghent University, Ghent, Belgium;5. Cancer Research Institute (CRIG), Ghent University, 9000 Ghent, Belgium;6. Department of Biomolecular Medicine, Ghent University, Ghent, Belgium;1. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;2. Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA;3. Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA;4. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA;1. Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK;2. Institute of Cellular Medicine, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK;1. Information and Operation Branch, Tel-Aviv Sourasky Medical Center, 6 Weizmann St., Tel-Aviv 6423906, Israel;2. Allergy and Clinical Immunology Unit, Department of Medicine, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, 6 Weizmann St., Tel-Aviv 6423906, Israel;3. Sackler Faculty of Medicine, University of Tel Aviv, 6 Weizmann St., Tel-Aviv 6423906, Israel;4. Laboratory of Biomarkers and Genomic of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel |
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| Abstract: | Antigenic beta-lactoglobulin and alpha-casein were measured in the sera of 45 formula-fed infants of 31 to 41 weeks of gestation at 5 days and at 10 days of age. Quantitation was performed by a sensitive ELISA inhibition assay. On day 5 of life antigenic lactoglobulin was detected in 14 of 19 infants of less than 37 weeks gestation, but in only one of 10 infants of more than 36 weeks gestation. On day 10 of life the sera of all infants contained antigenic lactoglobulin. In contrast, on day 5 antigenic casein was present in four of 17 infants of less than 37 weeks gestation, but in 10 of 12 infants of the more mature group. On day 10 casein was detected in seven of 28 infants, with no difference between groups; anti-casein was found in eight of 12 infants. Infants of less than 37 weeks gestation have different absorption patterns than more mature infants do. "Gut closure" is an unlikely explanation for these findings. |
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