复方磺胺嘧啶锌涂膜与湿润烧伤膏在不同烧伤创面的应用策略

目的探讨复方磺胺嘧啶锌涂膜与湿润烧伤膏治疗烧伤浅Ⅱ度、深Ⅱ度及其感染创面的疗效。方法将156例烧伤病人按入院日期单、双日分为两组，A组病人创面用复方磺胺嘧啶锌涂膜，B组病人创面用湿润烧伤膏，观察两组的止痛、创面炎症控制、抑菌效果、创面愈合时间、换药次数及不良反应。结果止痛效果B组优于A组（P〈0．01）；换药中创面炎症控制方面A组优于B组；Ⅱ度创面A组用药前细菌培养阳性率40．3％，治疗中降至9．6％，B组用药前细菌培养阳性率为39．6％，治疗中升至60．3％，两组间比较差异有显著性意义（P〈0．01），感染创面A组用药后细菌定量少于B组（P〈0．01）；创面愈合时间：浅Ⅱ度A组（12±2．9）天，B组（15±2．8）天（P〈0．05），深Ⅱ度创面，A组（27±3．5）天，B组（49±8．3）天（P〈0．01）；换药次数，A组明显少于B组（P〈0．01）。结论湿润烧伤膏在止痛效果方面优于复方磺胺嘧啶锌涂膜，建议在浅Ⅱ度、面积小的创面使用；复方磺胺嘧啶锌涂膜在预防、控制创面感染，加快创面愈合等方面优于湿润烧伤膏，适用于深Ⅱ度及感染创面。

Application Strategy of Agent SD-Ag-Zn and Moist Burn Ointment in Treatment of Burn Wounds

Objective To observe the effect of Agent SD-Ag-Zn and Moist Burn Ointment in treatment of burn wounds. Methods One hundred and fifty-six burn patients were randomly divided into two groups treated with Agent SD-Ag-Zn （group A） and Moist Burn Ointment （group B） respectively. The analgesic effect, inhibition of wound inflammation, wound healing time, dressing change times and side effects were observed and compared. Results The analgesic effect in group B was better than in group A （P〈0. 01）, while the inflammation inhibition effect in group A was better than in group B. In second-degree burns, the positive rate of bacteria culture went down from 40. 3% to 9. 6% in group A while rose from 39. 6% to 60. 3% in group B. There was significant difference between two groups （P〈0. 01）. For superficial second-degree burns, the wound healing time was （12 ± 2. 9） days in group A and （15±2. 8） days in group B （significantly different between two groups, P〈0. 05） ; for deep second-degree burns, the healing time was （27 ± 3. 5） days and （49 ± 8. 3） days respectively （significantly different between two groups, P〈0. 01）. Dressing change times in group A were apparently fewer than in group B （P〈0. 01）. Conclusion Moist Burn Ointment is superior to the Agent SD-Ag-Zn in analgesic effect while the latter is superior in preventing and controlling wound infection, and promoting wound healing.