肝纤维化血清学指标与乙型和丙型肝炎关系的临床流行病学分析

目的评价血清HA,LN,PⅢP,IV-C联检在乙型和丙型肝炎肝纤维化诊断中的价值,分析乙、丙型急性肝炎转为慢性的变化情况。方法157例乙型肝炎和47例丙型肝炎和40例健康成人组采用ELISA法测定4项肝纤维化血清学指标。结果HA,LN,IV-C 3项指标明显高于健康成人组,各组间的检测指标水平随肝病组织炎症程度而增高;慢性丙型肝炎阳性检出率明显高于急性丙型肝炎,慢性乙型肝炎阳性检出率与急性乙型肝炎相近。结论3项指标联合应用对肝纤维化程度的判断有诊断价值;丙型肝炎比乙型肝炎更容易转化为慢性。

Clinical Epidemic Analysis of Relationship Between Serologic Indicators of Hepatic Fibrosis and Hepatitis B and C

Objective To evaluate the effect of combined examination of serum HA,LN,PⅢhepatitis P（PⅢP） and IV-C on diagnosis of hepatic fibrosis,and analyze chronic progress of acute hepatitis B and C.Methods ELISA method was used for testing four serological indicators of hepatic fibrosis among 157 patients with hepatitis B（HB）,47 patients with hepatitis C（HC） and 40 healthy people.Results Serum concentration of HA,LN and IV-C was significantly higher than those of the healthy group and increased with progression of hepatic tissue inflammation.They were relatively higher in the chronic hepatitis C（CHC） than in the acute hepatitis C（AHC）,and similar in the chronic hepatitis B（CHB） to those in the acute hepatitis B（AHB）.Conclusions The results indicates that combined application of the three indicators are valuable for diagnosis of hepatic fibrosis.HC is easier to turn into the chronic than HB does.