丙泊酚联合右美托咪定在美容手术中的应用效果

目的 分析丙泊酚联合右美托咪定在美容手术中的应用效果。方法 选取2020年1月-2022年12月 于我院行美容手术的80例患者为研究对象,随机分为对照组和观察组,每组40例。对照组采用丙泊酚联合 舒芬太尼进行麻醉,观察组采用丙泊酚联合右美托咪定进行麻醉,比较两组不良反应发生情况、血流动力 学指标[心率（HR）、平均动脉压（MAP）]、应激反应指标[（皮质醇（Cor）、肾上腺素（NE）]及相关 疼痛介质指标[血清P物质（SP）、5-羟色胺（5-HT）、前列腺素E2（PGE2）]。结果 观察组不良反应发生 率为7.50%,低于对照组的25.50%（P＜0.05）;观察组T1~T3时Cor、HR、NE水平均低于对照组,MAP水 平高于对照组（P＜0.05）;两组术后24 h血清SP、5-HT、PGE2水平均高于麻醉诱导前,但观察组低于对 照组（P＜0.05）。结论 丙泊酚联合右美托咪定在美容手术中的麻醉效果确切,在发挥镇静镇痛作用的同 时,可有效改善患者的应激反应和血流动力学指标,且不会增加不良事件发生几率,值得临床应用。

Application Effect of Propofol Combined with Dexmedetomidine in Cosmetic Surgery

Objective To analyze the application effect of propofol combined with dexmedetomidine in cosmetic surgery. Methods A total of 80 patients who underwent cosmetic surgery in our hospital from January 2020 to December 2022 were randomly divided into control group and observation group, with 40 cases in each group. The control group was anesthetized with propofol combined with sufentanil, and the observation group was anesthetized with propofol combined with dexmedetomidine. The incidence of adverse reactions, hemodynamic indexes [heart rate (HR), mean arterial pressure (MAP)], stress response indexes [(cortisol (Cor), epinephrine (NE)] and related pain mediators [serum substance P (SP), 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2)] were compared between the two groups. Results The incidence of adverse reactions in the observation group was 7.50%, which was lower than 25.50% in the control group (P