新疆不同民族贲门腺癌组织中IGF-IR、p53的表达及其病理学意义

目的：探讨新疆不同民族贲门腺癌与非癌组织中IGF—IR、p53的异常表达及其病理学意义。方法：应用免疫组化LSAB法检测93例贲门腺癌和21例非癌组织的IGF-IR、p53水平，并分析其表达与病理学意义。结果：（1）IGF～IR、p53在贲门腺癌组织中的检出率分别为84．95％（79／93）、75．27％（70／93），在贲门非癌组织中的阳性检出率分别为47．62％（10／21）、4．76％（1／21），差异均有统计学意义（P〈0．01）。（2）哈萨克、维吾尔、汉族民族间IGF—IR、p53阳性率差别均无统计学意义（P〉0．05）。（3）p53的阳性表达与组织分级无关（P〉0．05），而与淋巴结转移相关（P〈0．05）。IGF-IR的阳性表达与贲门腺癌组织学分级及淋巴结转移无明显关系（P〉0．05）。（4）贲门腺癌中IGF-IR与p53间未发现有相关关系（P〉0．05）。结论：IGF-IR和p53的异常表达在贲门腺癌变过程中具有重要作用。

Biopathological significance of the abnormal expression of IGF-IR, p53 in cardiac cancer tissues in Xinjiang

Objective: To detect the abnormal expression of IGF-IR protein, p53 oncogene in cardiac cancer tissues in different ethnic patients, may involve the molecular biology of cardiac carcinogenesis. Methods: The over expression of IGF-IR and p53 on paraffin embedded tumor tissues in 93 different ethnic patients with cardinal adenocarcinoma (Hazak 30, Uygur 32, Han 31) were examined by immunohistochemistry (LSAB). Results: The positive frequency of IGF-IR and p53 in cardial cancer were 84.95%(79/93), 75.27% (70/93) respectively. And the expression of those in non-cancer were 47.62%(10/21), 4.76% (1/21) . There was statistic significance between cancer and non-cancer (P<0.01). The statistic significance was found between the expression of p53 and the metastasis in lymph node (P<0.05). However, no difference of the expression of IGF-IR, p53 among different ethnic as well as varing degrees of differentiation was found (P>0.05). No significant correlationship was found between IGF-IR and p53 (P> 0.05) . Conclusion: The abnormal expression of IGF-IR and p53 may be an important etiopathogenesis factor for cardiac carcinogenesis. No statistic difference on the expression of IGF-IR and p53 among different ethnic was found as well as varing degrees of differentiation. The abnormal expression of p53 had relationship with matestasis of lymph node incardiac cancer.