丙基硫氧嘧啶致超敏反应综合征合并胰腺 炎简

1 例21 岁男性患者,因甲状腺功能亢进入院,无既往病史及饮酒史.入院给予丙基硫氧嘧啶（10 mg,tid）,治疗23 d后患者出现皮疹、发热及肝功能损害,经停药、抗过敏及保肝治疗5 d 后好转.再次给予丙基硫氧嘧啶,用药1 d 后患者再次出现发热、皮疹,严重肝功能损害,ALT最高达407.9 IU·L-1,并在停药4 d后并发了急性胰腺炎,经抗过敏保肝及对症治疗27 d后好转.

Propylthiouracil-induced hypersensitivity syndrome and pancreatitis

One case of 21-year-old male patient with hyperthyroidism was admitted to the hospital, who had no previousmedical history and drinking history. After admission the patient was given propylthiouracil （10 mg, tid）. The patient developed rash,fever and liver dysfunction after 23 days with the treatment. The condition improved after stopping drug, as well as antiallergic andhepatoprotective treatment for 5 days. But the patient had fever, rash, severe liver dysfunction again after reuse of propylthiouracil for1 day, and ALT was 407.9 IU·L-1. The patient developed acute pancreatitis 4 days after the withdrawal of propylthiouracil. Throughantiallergic, hepatoprotective and symptomatic treatment for 27 days, the condition improved.