不同皮肤组织对安替比林贴片经皮渗透的差异

目的：评价皮肤角质层和活性皮肤层对药物经皮渗透的差异。方法：选择安替比林（AT）为模型药物，采用Franz扩散池法，考察药物经完整皮肤和剥离角质层皮肤的体外透皮能力Kp，并比较吸收促进剂肉豆蔻酸异丙酯（IPM）共存时的促透能力大小。结果：AT经剥离角质层皮肤的Kp是经完整皮肤的3.24倍，加入IPM后AT的Kp分别提高到原来的3.68倍（经完整皮肤）和5.17倍（经剥离角质层皮肤）。结论：本实验为皮肤病态条件，如皮肤受伤或溃疡等时的药物经皮吸收规律研究提供一种新的方法。

Influence of different skin tissue on the percutaneous absorption of antipyrine patch

OBJECTIVE To investigate the influence of skin layers (stratum corneum and viable layer) on the percutaneous absorption of drug with or without isopropyl myristate (IPM). METHOD We chose antipyrine (AT) as a model drug. Patches containing saturated concentration of AT were prepared. The in vitro transdermal permeation experiment via different rat skin layers was carried out. RESULTS The Kp value of AT via stripped skin was 3.24 times than that via intact skin. The permeability was enhanced with the KP values being 3.68 and 5.17 times when coexisting with IPM via intact or stripped skin respectively.CONCLUSION These data and methods provide a novel approach to evaluate the effects of skin damage and skin disease on drug percutaneous absorption.