| 参松养心胶囊对兔跨室壁复极离散度的影响 |
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| 引用本文： | 徐涛,张煜,王昊,廖德宁.参松养心胶囊对兔跨室壁复极离散度的影响[J].疑难病杂志,2011,10(12):916-918. |
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| 作者姓名： | 徐涛 张煜 王昊 廖德宁 |
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| 作者单位： | 第二军医大学长征医院心内科,上海,200003 |
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| 摘 要： | 目的观察参松养心胶囊对兔跨壁复极离散度(TDR)的影响,为阐述参松养心胶囊抗心律失常机制以及药物安全性提供实验依据。方法 20只兔随机分为2组,参松养心组(予参松养心胶囊1g/kg,n=10)和健康对照组(予等量生理盐水,n=10),2周后均建立冠脉灌注左室楔形心肌组织块模型,在不同基础刺激周长(BCL)下,记录2组兔TDR的变化。结果 (1)与健康对照组比较,参松养心组兔内、外膜心肌细胞的动作电位时程(APD)延长,当BCL分别为500 ms、1000 ms、2000 ms、4000 ms时,心内、外膜APD均有不同程度延长,参松养心组同健康对照组相比,差异均有统计学意义(P<0.01)。(2)与健康对照组比较,参松养心组TDR显著缩短,差异有统计学意义(P<0.01)。结论参松养心胶囊可延长心肌内、外膜细胞APD,有效减小TDR,从而发挥抗心律失常作用。
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| 关 键 词： | 电生理学 跨壁复极离散度 参松养心胶囊 动作电位时程 兔 |
Effects of Shensongyangxin capsule on transmural dispersion of re-polarization in rabbit model |
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| XU Tao,ZHANG Yu,WANG Hao,et al..Effects of Shensongyangxin capsule on transmural dispersion of re-polarization in rabbit model[J].Journal of Difficult and Complicated Cases,2011,10(12):916-918. |
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| Authors: | XU Tao ZHANG Yu WANG Hao |
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| Institution: | XU Tao,ZHANG Yu,WANG Hao,et al.Department of Cardiology,Changzheng Hospital Affiliated to the Second Military Medical University,Shanghai 200003,China |
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| Abstract: | Objective To investigate the effects of Shensongyangxin capsule on transmural dispersion of re-polarization(TDR) in rabbit model,and provide experimental evidence to explain the anti-arrhythmic mechanism and drug safety of Shensongyangxin capsule.Methods 20 rabbit were randomly allocated into Shensongyangxin capsule group(1 g/kg,n= 10) and control group(with same dose of saline,n=10).After 2 weeks,the arterially perfuse left ventricular wedge model were established in all rabbits.The transmural ECG and tran... |
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| Keywords: | Electrophysiology Transmural dispersion of re-polarization Shensongyangxin capsule Action potential duration Rabbit |
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