| ~(32)磷-玻璃微球治疗裸鼠人肝癌移植瘤的超微结构观察和立体定量学研究 |
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| 引用本文： | 张东生,刘璐,万美玲,李群慧. ~(32)磷-玻璃微球治疗裸鼠人肝癌移植瘤的超微结构观察和立体定量学研究[J]. 肿瘤防治研究, 2002, 29(4): 293-294,F002 |
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| 作者姓名： | 张东生 刘璐 万美玲 李群慧 |
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| 作者单位： | 1. 210009,南京,东南大学医学院电镜室
2. 210009,南京,东南大学医学院放免中心 |
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| 摘 要： | 目的 探讨32 P GMS对肝癌的治疗作用和超微结构影响。方法 建立裸鼠人肝癌移植瘤后用32 P GMS进行治疗 ,取治疗后瘤组织进行电镜观察和立体定量学研究。结果 实验组瘤细胞大量坏死 ,部分瘤细胞出现了高分化肝癌的形态特征。实验组线粒体和粗面内质网体密度、毛细胆管和微绒毛面密度高于对照组(P <0 .0 1、0 .0 5、0 .0 1)。结论 研究表明32 P GMS抗肝癌作用明显 ,并具有较好的促分化功能
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| 关 键 词： | 肝肿瘤 32磷-玻璃微球 超微结构 立体定量学 |
| 文章编号： | 1000-8578(2002)04-0293-02 |
| 收稿时间： | 2001-08-20 |
| 修稿时间： | 2002-12-30 |
An ultrastructural and morphometric study on the effect of phosphorus-32 glass microspheres (32P-GMS) on the human hepatocellular carcinoma in nude mice |
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| ZHANG Dong|sheng,LIU Lu,WAN Mei|ling,et al Laboratory of Electron Microscopy,Medical College of Southeast University,Nanjing ,China. An ultrastructural and morphometric study on the effect of phosphorus-32 glass microspheres (32P-GMS) on the human hepatocellular carcinoma in nude mice[J]. Cancer Research on Prevention and Treatment, 2002, 29(4): 293-294,F002 |
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| Authors: | ZHANG Dong|sheng LIU Lu WAN Mei|ling et al Laboratory of Electron Microscopy Medical College of Southeast University Nanjing China |
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| Affiliation: | ZHANG Dong|sheng,LIU Lu,WAN Mei|ling,et al Laboratory of Electron Microscopy,Medical College of Southeast University,Nanjing 210009,China |
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| Abstract: | Objective To study anticancer effect and ultrastructural influnce of 32 P|GMS injected to the hepatocellular carcinoma in nude mice.Methods The ultrastructural changes of tumor was examined by electron microscope and stereology . Results In treated group, a lot of tumor cells (35%～70%) were killed.Ultrastructurally,severe nuclear damage was observed in the death cells. Besides, well differentiated and degenerative tumor cells were seen.The skin and muscle neighboring to the t... |
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| Keywords: | Liver Tumor 32|Phosphorus Glass Microsphere Ultrastructure Morphometry |
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