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| HLA-G蛋白在子宫腺肌病中的表达及其作用机制 | |
| 引用本文： | 赵倩,任云青,薛丽萍,李培莉,王亚香. HLA-G蛋白在子宫腺肌病中的表达及其作用机制[J]. 中国免疫学杂志, 2010, 26(6). DOI: 10.3969/j.issn.1000-484X.2010.06.007 |
| 作者姓名： | 赵倩 任云青 薛丽萍 李培莉 王亚香 |
| 作者单位： | 1. 山西医科大学,太原,030001 2. 山西医科大学汾阳学院,汾阳,032200 3. 山西省汾阳医院妇产科,汾阳,032200 |
| 摘 要： | 目的:探讨HLA-G蛋白在子宫腺肌病中的作用机制。方法:采用免疫组织化学染色方法与Western blot方法检测31例子宫腺肌病患者在位与异位内膜组织HLA-G蛋白表达,18例子宫肌瘤患者正常子宫内膜作为对照。结果:子宫腺肌病患者在位与异位内膜组织腺上皮、间质细胞均有HLA-G蛋白表达,而子宫肌瘤患者(对照组)正常内膜中未检测到HLA-G蛋白;子宫腺肌病患者在位与异位内膜组织HLA-G蛋白表达无显著性差异(P0.05);子宫腺肌病患者在位内膜分泌期和增生期HLA-G蛋白表达无显著性差异(P0.05)。结论:子宫腺肌病患者在位与异位内膜组织HLA-G蛋白异常表达,可能与其发病有关。 |
| 关 键 词： | 人类白细胞抗原-G 子宫腺肌病 免疫耐受 |
Expression of HLA-G protein in adenomyosis and its functions |
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| ZHAO Qian,REN Yun-Qing,XUE Li-Ping,LI Pei-Li,WANG Ya-Xiang. Expression of HLA-G protein in adenomyosis and its functions[J]. Chinese Journal of Immunology, 2010, 26(6). DOI: 10.3969/j.issn.1000-484X.2010.06.007 | |
| Authors: | ZHAO Qian REN Yun-Qing XUE Li-Ping LI Pei-Li WANG Ya-Xiang |
| Affiliation: | ZHAO Qian,REN Yun-Qing,XUE Li-Ping,LI Pei-Li,WANG Ya-Xiang.Shanxi Medical University,Taiyuan 030001,China |
| Abstract: | Objective:To investigate the role of HLA-G protein in the pathogenesis of adenomyosis.Methods:Immunohistochemistry and Western blot methods were used for detecting the expression of HLA-G protein in eutopic endometrium and ectopic endometrial tissues of 31 patients with adenomyosis (AM),normal endometrial tissues of 18 patients only with hysteromyoma were recruited as control group.Results:The expression of HLA-G was in glandular and stromal cells in eutopic and ectopic endometrium of patients with AM,where... |
| Keywords: | Human leukocyte antigen-G Adenomyosis Immune tolerance |
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