| TRAIL-DR4启动子区基因多态性与肺癌易感性的相关性研究 |
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| 引用本文： | 黄惠娟,欧阳学农,赵忠全,余宗阳. TRAIL-DR4启动子区基因多态性与肺癌易感性的相关性研究[J]. 肿瘤学杂志, 2011, 17(1): 46-49 |
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| 作者姓名： | 黄惠娟 欧阳学农 赵忠全 余宗阳 |
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| 作者单位： | 福建医科大学福州总医院临床医学院,福建,福州,350025 |
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| 摘 要： | [目的]初步探讨TRAIL死亡受体4（DR4）基因多态性与肺癌易感性的关系。[方法]采用PCR-RFLP技术,对92例肺癌患者和92例健康对照者的DR4基因启动子区的-972C/T和-397G/T多态性位点基因型进行检测。以非条件Logistic回归校正混杂因素进行相关性分析。[结果]TRAIL-DR4基因-972C/T位点多态性与肺癌易感性无明显相关性;在吸烟≥20年的人群中含有-397G/T位点T等位基因（GT＋TT）比GG纯合基因型的肺癌发病风险增加（OR=3.462,95%CI：1.222～9.811,P=0.019）。[结论]DR4基因多态性与肺癌的易感性间存在一定的关系。
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| 关 键 词： | 肺肿瘤 TRAIL DR4 易感性 基因多态性 |
Correlation of TRAIL-DR4 Genetic Polymorphism with Susceptibility for Lung Cancer |
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| HUANG Hui-juan,OUYANG Xue-nong,ZHAO Zhong-quan,et al.. Correlation of TRAIL-DR4 Genetic Polymorphism with Susceptibility for Lung Cancer[J]. Journal of Chinese Oncology, 2011, 17(1): 46-49 |
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| Authors: | HUANG Hui-juan OUYANG Xue-nong ZHAO Zhong-quan et al. |
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| Affiliation: | HUANG Hui-juan,OUYANG Xue-nong,ZHAO Zhong-quan,et al.(Fuzhou General Hospital of Fujian Medical University,Fuzhou 350025,China) |
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| Abstract: | [Purpose] To investigate the correlation TRAIL-DR4 of genetic polymorphism with susceptibility for lung cancer.[Method] The genotypes of-972C/T and-397G/T polymorphic loci at TRAIL-DR4 gene promoter region were determined by PCR-RFLP method in 92 cases with lung cancer and 92 healthy controls.The statistical association of genotypes in the two groups adjusted by gender,age and smoke was analyzed by unconditional Logistic regression model.[Results] The-972C/T polymorphic loci at TRAIL-DR4 gene promoter regio... |
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| Keywords: | TRAIL DR4 |
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