| 注射用兰索拉唑在健康人体内的药动学研究 |
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| 引用本文： | 张杰,何世英,阳国平,周彦彬,田娟,丁劲松. 注射用兰索拉唑在健康人体内的药动学研究[J]. 中南药学, 2011, 9(3): 169-172. DOI: 10.3969/j.issn.1672-2981.2011.03.003 |
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| 作者姓名： | 张杰 何世英 阳国平 周彦彬 田娟 丁劲松 |
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| 作者单位： | 1. 中南大学药学院,长沙,410013
2. 中南大学湘雅三医院,长沙,410013 |
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| 摘 要： | 目的研究兰索拉唑在健康受试者体内的药动学过程。方法采用三交叉拉丁方设计,12名健康受试者分别静脉滴注兰索拉唑15、30、60 mg(45 min滴完),洗脱期为1周。血浆中兰索拉唑的浓度以HPLC-UV法测定,以DAS Ver 2.1计算药动学参数。结果受试者静脉滴注兰索拉唑后体内过程符合二室模型,单次给药15、30、60 mg后主要药动学参数:t1/2分别为(1.76±1.43)、(1.21±0.4)、(1.86±1.29)h,Cmax分别为(0.92±0.33)、(2.05±0.59)、(4.04±0.55)μg.mL-1,AUC0-10h分别为(3.41±2.14)、(6.25±3.55)、(11.65±5.96)μg.h.mL-1,AUC0-∞分别为(7.67±6.37)、(9.21±7.13)、(14.68±10.01)μg.h.mL-1,V分别为(5.95±5.18)、(6.32±3.74)、(5.26±6.03)L,CL分别为(3.98±4.38)、(4.81±2.18)、(5.43±2.43)L.h-1。结论中国健康受试者单剂量静脉滴注兰索拉唑后,在15~60 mg内的体内过程呈线性药动学特征。兰索拉唑在人体的代谢存在较大的个体差异,变异来源可能与CYP2C19的基因多态性有关,临床宜个体化用药。
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| 关 键 词： | 兰索拉唑 药动学 高效液相色谱-紫外法 CYP2C19 |
Pharmacokinetics of lansoprazole injection in healthy volunteers |
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| ZHANG Jie,HE Shi-ying,YANG Guo-ping,ZHOU Yan-bin,TIAN Juan,DING Jin-song. Pharmacokinetics of lansoprazole injection in healthy volunteers[J]. Central South Pharmacy, 2011, 9(3): 169-172. DOI: 10.3969/j.issn.1672-2981.2011.03.003 |
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| Authors: | ZHANG Jie HE Shi-ying YANG Guo-ping ZHOU Yan-bin TIAN Juan DING Jin-song |
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| Affiliation: | ZHANG Jie1,HE Shi-ying1,YANG Guo-ping2,ZHOU Yan-bin1,TIAN Juan1,DING Jin-song1*(1.School of Pharmaceutical Sciences,Central South University,Changsha 410013,2.Third Xiangya Hospital,Changsha 410013) |
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| Abstract: | Objective To determine the pharmacokinetics in healthy volunteers following intravenous administration of lansoprazole.Methods A three-way crossover Latin square design was applied.Twelve healthy volunteers were randomized to administer a single dose of lansoprazole at 15,30 and 60 mg,respectively.Wash-out period lasted a week.The concentration of lansoprazole in human plasma was determined by HPLC-UV.The main pharmacokinetic parameters were calculated with DAS Ver 2.1.Results The pharmacokinetics of lansop... |
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| Keywords: | CYP2C19 |
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