| 硝普钠在糖尿病患者适用输液体系中的稳定性考察 |
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| 引用本文： | 余永,吴娜,鲁小民. 硝普钠在糖尿病患者适用输液体系中的稳定性考察[J]. 中南药学, 2011, 9(2): 121-123. DOI: 10.3969/j.issn.1672-2981.2011.02.013 |
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| 作者姓名： | 余永 吴娜 鲁小民 |
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| 作者单位： | 湘阴县人民医院,湖南,岳阳,414600 |
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| 摘 要： | 目的考察室温条件下硝普钠与胰岛素在5%葡萄糖注射液中以及硝普钠在木糖醇注射液中的稳定性。方法采用高效液相色谱法测定输液配制后14 h内各药的含量变化,同时观察期间输液的pH值、外观和微粒数的变化情况。结果各输液配制后,室温下0~14 h的外观、pH值、药物含量均无明显变化,各时间点的微粒数均符合药典要求。结论在室温条件下,14 h内硝普钠与胰岛素在5%葡萄糖注射液中以及硝普钠在木糖醇注射液中性质稳定。
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| 关 键 词： | 胰岛素 硝普钠 木糖醇 稳定性 高效液相色谱法 |
Stability of sodium nitroprusside in 2 different infusion solutions for diabetic patients |
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| YU Yong,WU Na,LU Xiao-min. Stability of sodium nitroprusside in 2 different infusion solutions for diabetic patients[J]. Central South Pharmacy, 2011, 9(2): 121-123. DOI: 10.3969/j.issn.1672-2981.2011.02.013 |
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| Authors: | YU Yong WU Na LU Xiao-min |
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| Affiliation: | YU Yong,WU Na,LU Xiao-min(People's Hospital of Xiangyin,Yueyang Hunan 414600) |
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| Abstract: | Objective To study the stability of sodium nitroprusside and insulin in 5% glucose injection,and sodium nitroprusside in xylitol injection at room temperature.Methods We determined the drug concentration at different time points after the solution was prepared by HPLC,and observed the variation of solution PH,appearance,and particle numbers.Results There was no significant change at 14 h at room temperature.Conclusion Sodium nitroprusside and insulin are stable in the 2 injections within 14 h at room temper... |
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| Keywords: | insulin sodium nitroprusside xylitol stability HPLC |
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