| 利拉萘酯乳膏含量测定方法学的探讨 |
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| 引用本文： | 龙红萍,徐康平,丁劲松,刘海乐,谭桂山. 利拉萘酯乳膏含量测定方法学的探讨[J]. 中南药学, 2011, 9(1): 23-25. DOI: 10.3969/j.issn.1672-2981.2011.01.008 |
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| 作者姓名： | 龙红萍 徐康平 丁劲松 刘海乐 谭桂山 |
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| 作者单位： | 1. 中南大学药学院,长沙,410013;湖南永州职业技术学院药学系,湖南永州,425100
2. 中南大学药学院,长沙,410013 |
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| 摘 要： | 目的建立RP-HPLC法测定利拉萘酯乳膏中利拉萘酯的含量。方法采用Agilent C18色谱柱(150 mm×4.6 mm,5μm),流动相为乙腈-水(65∶35),柱温为35℃,检测波长为284 nm,流速为1.2 mL.min-1。结果利拉萘酯在40~200μg.mL-1与峰面积线性关系良好(r=0.999 9),平均回收率99.1%,RSD为0.86%。结论该方法简便、快速、准确、灵敏度高、重复性好,可用于利拉萘酯乳膏含量的测定。
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| 关 键 词： | 利拉萘酯 反相高效液相色谱法 |
Determination of the content of liranaftate cream |
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| LONG Hong-ping,XU Kang-ping,DING Jing-song,LIU Hai-le,TAN Gui-shan. Determination of the content of liranaftate cream[J]. Central South Pharmacy, 2011, 9(1): 23-25. DOI: 10.3969/j.issn.1672-2981.2011.01.008 |
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| Authors: | LONG Hong-ping XU Kang-ping DING Jing-song LIU Hai-le TAN Gui-shan |
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| Affiliation: | LONG Hong-ping1,2,XU Kang-ping1,DING Jing-song1,LIU Hai-le1,TAN Gui-shan1(1.School of Pharmaceutical Sciences,Central South University,Changsha 410013,2.Department of Pharmacy,Yongzhou Vocational and Technical College,Yongzhou Hunan 425100) |
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| Abstract: | Objective To establish an RP-HPLC method to determine the content of liranaftate cream. Methods Agi- lent C18 （150 min×4.6 mm, 5μm） was used, the mobile phase was acetonitribe-water （65 ： 35） , the temperature was 35 ℃, and the detective wavelength was 284 nm at 1.2 mL·min^-1. Results The linear range of liranaftate was 40--200μg·mL^-1 （r=0. 999 9）, the average recovery was 99.1%（RSD=0. 86%）. Conclusion The method is convenient, fast, accurate, and sensitive. The reproducibility is high for the content determination of liranaftate cream. |
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| Keywords: | liranaftate RP-HPLC |
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