环氧合酶-2和survivin在B细胞非霍奇金淋巴瘤中的表达及意义

摘要 目的： 探讨COX-2和Survivin在B细胞非霍奇金淋巴瘤(B-NHL)中的表达及临床意义。方法： 采用免疫组化SP法检测43例B-NHL和10例良性淋巴结病变组织中COX-2和Survivin的表达。 结果： COX-2和Survivin在B-NHL中的阳性表达率分别为55.8％（24/43）和69.8％（30/43），与对照组相比差异具有显著性（P分别＜0.05和0.01）。Ⅲ/Ⅳ期B-NHL患者COX-2蛋白的表达要高于Ⅰ/Ⅱ期患者 （P＜0.05）。Survivin的表达与B-NHL的组织病理学等级和国际预后指数（IPI）具有相关性（P＜0.05）。Spearman相关分析表明COX-2的表达与Survivin的表达呈正相关（r=1.000,P=0.030）。 结论： COX-2和Survivin在B-NHL中表达上调以及两者之间的阳性表达密切相关，表明COX-2和Survivin在B-NHL的发生和发展中具有协同作用。

Expression and clinical significance of COX-2 and survivin in B cell non-Hodgkin''''s lymphoma

［Abstract］ Objective The purpose of this study is to investigate the expression and clinical significance of COX-2 and Survivin in B-NHL(B cell non-Hodgkin’s lymphoma, B-NHL). Methods The expression of COX-2 and Survivin in 43 cases of B-NHL and 10 cases of benign lymph node lesions were detected by immunohistochemical streptavidin-biotin peroxidase method . Results The expression rate of COX-2 and Survivin in B-NHL was 55.8%(24/43) and 69.8%(30/43) respectively. Compared with the control, the difference was statistically significance （P＜0.05 or P＜0.01）. The expression of COX-2 in B-NHL patients with stage Ⅲ /Ⅳ was higher than that of patients with stage Ⅰ/Ⅱ（P＜0.05）.The expression of Survivin was related with histopathologic grade and IPI of B-NHL（P＜0.05）. Spearman’s correlation analysis showed COX-2 expression was positively correlated with Survivin expression（r=1.000, P=0.030）. Conclusions The specific up-regulation of COX-2 and Survivin in B-NHL and the positive correlation between expression of COX-2 and Survivin showed that they had an synergistic effect in the development and progression of B-NHL.