加味血府逐瘀汤对H22移植性肿瘤小鼠抗肿瘤作用的研究

目的 探讨加味血府逐瘀汤对腹水型H22移植性肿瘤小鼠的抗肿瘤作用和对血管内皮生长因子(VEGF)的影响.方法 昆明种雄性小鼠100只,接种H22肝癌细胞,建立小鼠腹水型H22移植性肿瘤模型,按体重分层随机分为5组各10只,分别给予生理盐水、卡培他滨、加味血府逐瘀汤高、中、低剂量灌胃,连续10 d,第11天处死,观察抑瘤...

The experimental research anti-tumor effect of modified decoction for driving out blood stasis in the blood mannsion

Objective Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion on ascites tumor model of transplanted H22 anti-tumor effect and the impact of VEGF. Methods Adult male mice 100, inoculated with H22 hepatoma cells, the establishment of ascites H22 transplanted tumor model, then divided into 10 groups were given saline, capecitabine, flavored Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion (high, medium and low dose) was administered orally for 10 days, 11 days of treatment, observation of suppression tumor rate, the rate of change in life extension; detected by immunohistochemistry the expression of VEGF in tumors, SPSS13.0 software for statistical analysis. Results Capecitabine, flavored Xuefuzhuyutang (high, medium and low dose) inhibited tumor growth rates were 60%, 49%, 41%, 35%, life extension rate of the three groups were 1.68% 157.98%, 70.58%, 49.57% higher. Conclusion Modified Decoction for Driving Out Blood Stasis in the Blood Mannsion can inhibit tumor cell proliferation in tumor-bearing mice, significantly prolonged the survival time of mice, reduce the tumor tissue and tumor tissue expression of VEGF.