| p90核糖体S6激酶通路在乳腺癌中的作用及其机制 |
| |
| 引用本文： | 夏冰,王钢. p90核糖体S6激酶通路在乳腺癌中的作用及其机制[J]. 国际肿瘤学杂志, 2011, 38(6): 441-443. DOI: 10.3760/cma.j.issn.1673-422X.2011.06.014 |
| |
| 作者姓名： | 夏冰 王钢 |
| |
| 作者单位： | 1. 广州军区广州总医院医学实验科,510010
2. 广州军区广州总医院干部病房一科,510010 |
| |
| 摘 要： | p90核糖体s6激酶(RSK) 50%人乳腺癌中过表达.RSK通过调节几种关键的乳腺癌相关蛋白而促进乳腺癌细胞增殖.RSK还通过对mRNA转位和翻译的调节来促进肿瘤细胞存活.RSK还可促进乳腺癌的肿瘤血管形成,但RSK4可能具有抑制乳腺癌作用.BSK4之外的RSK可能是治疗乳腺癌很有前景的潜在靶点.
|
| 关 键 词： | 核糖体蛋白S6激酶,90-kDa 乳腺肿瘤 细胞增殖 存活 新生血管形成,病理性 |
Effects of p90 ribosomal S6 kinase pathway in breast cancer and its mechanism |
| |
| XIA Bing,WANG Gang. Effects of p90 ribosomal S6 kinase pathway in breast cancer and its mechanism[J]. Journal of International Oncology, 2011, 38(6): 441-443. DOI: 10.3760/cma.j.issn.1673-422X.2011.06.014 |
| |
| Authors: | XIA Bing WANG Gang |
| |
| Abstract: | p9O ribosomal S6 kinases(BSKs)are overexpressed in 50% human breast cancer. RSKs enhance the proliferation of breast cancer cells by regulating several key breast cancer-related proteins. They also improve survival of the breast cancer cells through regulating translocation and translation of mRNA. In addition. RSK promotes tumor angiogenesis by interaction with estrogen receptor. However, RSK4 may play an inhibitory role in breast cancer. In general, except RSK4,RSKs may become promising targets of breast cancer therapy. |
| |
| Keywords: | Ribosomal protein S6 kinases,90-kDa Breast neoplasms Cell proliferation Survival:Neovascularization,pathologic |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《国际肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《国际肿瘤学杂志》下载全文 |
