| 肿瘤干细胞的鉴定与分离 |
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| 引用本文： | 林之光,陈波斌. 肿瘤干细胞的鉴定与分离[J]. 国际肿瘤学杂志, 2011, 38(6): 411-413. DOI: 10.3760/cma.j.issn.1673-422X.2011.06.004 |
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| 作者姓名： | 林之光 陈波斌 |
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| 作者单位： | 复旦大学附属华山医院血液科,上海,200040 |
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| 基金项目： | 上海市自然科学基金资助项目 |
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| 摘 要： | 肿瘤干细胞被认为是肿瘤复发的根源.目前通过特定的免疫表型来分离鉴定肿瘤干细胞是最常用的方法.侧群(sP)细胞分离技术也已经相当成熟,利用Wnt通路在肿瘤细胞的表达活性差异来分离肿瘤干细胞的方法正受到关注.构建干细胞龛来捕获肿瘤干细胞的方法有待进一步评价.
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| 关 键 词： | 肿瘤干细胞 免疫表型分型 |
Identification and isolation of cancer stem cells |
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| LIN Zhi-guang,CHEN Bo-bin. Identification and isolation of cancer stem cells[J]. Journal of International Oncology, 2011, 38(6): 411-413. DOI: 10.3760/cma.j.issn.1673-422X.2011.06.004 |
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| Authors: | LIN Zhi-guang CHEN Bo-bin |
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| Abstract: | Cancer stem cells are considered to be the origin of tumor relapse.Isolating and identifying them by special immune-phenotypes is the most commonly used method.The technique of isolating SP cells is very mature.More attentions are being paid to the isolation of cancer stem cells using differential expression activities of Wnt pathway on surface of tumor cells.Establishing stem cells niches to capture cancer tumor cells remains to be further evaluated. |
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| Keywords: | Neoplastic stem cells Immunophenotyping |
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